Phospholipase C (PLC) Inositol phosphates + Ca2+

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Phospholipase C (PLC) Inositol phosphates + Ca2+ OH OPO3 OH HO OH OPO3 OH OH HO OH OPO3 INOSITOL INOSITOL TRIPHOSPHATE (IP3)

Production of IP3 and DAG BRADYKININ Phospholipase C phosphatidyl inositol P2 (PIP2) phosphatidyl inositol ATP phosphatases IP3 inositol ATP DAG phosphatidic acid

Ca2+ Production PLC PIP2 DAG IP3 Endoplasmic reticulum Ca2+ store Ca2+ INCREASED CONTRACTION SMOOTH MUSCLE CARDIAC MUSCLE INCREASED SECRETION FLUIDS HORMONES TRANSMITTERS Endoplasmic reticulum Ca2+ store Ca2+

Note rise in [Ca2+] may be transient because Ca2+ is rapidly depleted the response can be sustained if the Ca2+ is refilled directly from the extracellular space refilling stores may be the job of IP4

Ca2+ Release Ca2+ + + Ca2+ PIP2 IP4 IP3 Note - this mechanism is still speculative

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