Familial Nontoxic Multinodular Thyroid Goiter Locus Maps to Chromosome 14q but Does Not Account for Familial Nonmedullary Thyroid Cancer Graham R. Bignell,

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Familial Nontoxic Multinodular Thyroid Goiter Locus Maps to Chromosome 14q but Does Not Account for Familial Nonmedullary Thyroid Cancer Graham R. Bignell, Federico Canzian, Maryam Shayeghi, Markus Stark, Yin Y. Shugart, Patrick Biggs, Jonathan Mangion, Rifat Hamoudi, Jacalyn Rosenblatt, Paul Buu, Sophie Sun, Sheldon S. Stoffer, David E. Goldgar, Giovanni Romeo, Richard S. Houlston, Steven A. Narod, Michael R. Stratton, William D. Foulkes The American Journal of Human Genetics Volume 61, Issue 5, Pages 1123-1130 (November 1997) DOI: 10.1086/301610 Copyright © 1997 The American Society of Human Genetics Terms and Conditions

Figure 1 MON236 family. A reduced pedigree is shown with all typed individuals; bars denote all individuals with the at-risk haplotype, together with those required for clarification of recombinations. Blackened symbols denote multinodular goiter; an asterisk (*) indicates those with papillary tumors suggestive of papillary carcinoma; and a question mark (?) inside an unblackened symbol indicates that the individual was assigned to status “uncertain” in the linkage analysis. The alleles for the markers D14S287 (cen) to D14S65 are shown. The segregating haplotype is cen-4-3-2-2-4-4-4-3-1-3-2-1-2-5-3-4-3-7-1-tel, with the smallest region of sharing indicated in boldface. These four markers are D14S1054, D14S265, D14S1030, and D14S1455. For individual 29, the only portion of the at-risk haplotype retained is 3-2-1-2. Of the three individuals assigned status “uncertain,” individual 10 carriers the at-risk haplotype (3-2-1-2-5-3-4-3-?-1), whereas individual 15 does not; individual 22 is untyped but could not receive the linked haplotype. Individual 35 carries the at-risk haplotype but is unaffected. The American Journal of Human Genetics 1997 61, 1123-1130DOI: (10.1086/301610) Copyright © 1997 The American Society of Human Genetics Terms and Conditions