Histological evidence for endothelin (ET)-1 induction of epithelial-mesenchymal transition in rat primary distal epithelial cells. a–c) Control, d–f) ET-1.

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Histological evidence for endothelin (ET)-1 induction of epithelial-mesenchymal transition in rat primary distal epithelial cells. a–c) Control, d–f) ET-1. Histological evidence for endothelin (ET)-1 induction of epithelial-mesenchymal transition in rat primary distal epithelial cells. a–c) Control, d–f) ET-1. Immunofluorescence analysis demonstrated that ET-1 increases α-smooth muscle actin (α-SMA) expression, and that the increase is inhibited by BQ-123, an ET-A antagonist, but not BQ-788 an ET-B antagonist. a, d) α-SMA stained with DAPI. b, e) α-SMA stained with DAPI showed prominent intracellular stress fibres. c, f) Alveolar epithelial cells treated with ET-1 also changed morphology from a typical rounded shape to an elongated fibroblast-like morphology (phase images). BQ-123 prevented this morphological change, while BQ-788 did not. Reproduced from [15] with permission from the publisher. P. W. Noble Eur Respir Rev 2008;17:123-129 ©2008 by European Respiratory Society