Nervous elements influencing intestinal inflammation and rotavirus diarrhea may lead to new treatments Dan Gordon Gastroenterology Volume 118, Issue.

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Nervous elements influencing intestinal inflammation and rotavirus diarrhea may lead to new treatments Dan Gordon Gastroenterology Volume 118, Issue 4, (April 2000) DOI: 10.1016/S0016-5085(00)70128-4 Copyright © 2000 Terms and Conditions

Proposed mechanism by which mast cell activation utilizes release of the proteolytic enzyme tryptase to activate the proteinase-activated receptor 2 on substance P-containing spinal afferent neurons. Substance P released locally from these nerves acts on vascular endothelial cells to promote white blood cell infiltration and edema. This mechanism implicates local sensory neuronal activation and neuropeptide release in the inflammatory response produced by mast cells. Gastroenterology 2000 118, DOI: (10.1016/S0016-5085(00)70128-4) Copyright © 2000 Terms and Conditions