Volume 63, Issue 6, Pages (June 2003)

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Volume 63, Issue 6, Pages 2187-2193 (June 2003) Contributions of nitric oxide, EDHF, and EETs to endothelium-dependent relaxation in renal afferent arterioles Dan Wang, Lillian J. Borrego-Conde, John R. Falck, Kamalesh K. Sharma, Christopher S. Wilcox, Jason G. Umans Kidney International Volume 63, Issue 6, Pages 2187-2193 (June 2003) DOI: 10.1046/j.1523-1755.2003.00036.x Copyright © 2003 International Society of Nephrology Terms and Conditions

Figure 1 Relaxation of preconstricted endothelium intact (■) and denuded (▴) afferent arterioles. (A) Relaxation by acetylcholine (ACh). Intact, N = 9; denuded, N = 4. (B) Relaxation by sodium nitroprusside (SNP). Intact, N = 5; denuded, N = 4. Denudation abolished response to acetylcholine (*P < 0.05, intact vs. denuded) but did not alter relaxation due to SNP. Kidney International 2003 63, 2187-2193DOI: (10.1046/j.1523-1755.2003.00036.x) Copyright © 2003 International Society of Nephrology Terms and Conditions

Figure 2 Effects of nitric oxide synthase, cyclooxygenase (COX), and soluble guanylate cyclase inhibition as well as of elevated [K+] on acetylecholine (ACh)-induced relaxation of afferent arterioles.***P < 0.005 compared to control. aP < 0.05; bP < 0.001 compared to Nw-nitro-l-arginine (L-NNA) alone. Symbols are: (■) control; (□) indomethacin; (▴) L-NNA; (▵) methylene blue; (○) L-NNA + methylene blue; (•) L-NNA + K+. Kidney International 2003 63, 2187-2193DOI: (10.1046/j.1523-1755.2003.00036.x) Copyright © 2003 International Society of Nephrology Terms and Conditions

Figure 3 Effects of nitric oxide synthase inhibition and blockade of Ca2+ -activated K+ channels, alone or in combination, on acetylycholine (ACh)-induced relaxation of afferent arterioles. **P < 0.01; ***P < 0.005 compared to control. aP < 0.05; bP < 0.001 compared to Nw-nitro-l-arginine (L-NNA) alone. Symbols are: (■) control; (▴) L-NNA; (•) apamin + charybdotoxin; (○) L-NNA + apamin + charybdotoxin. Kidney International 2003 63, 2187-2193DOI: (10.1046/j.1523-1755.2003.00036.x) Copyright © 2003 International Society of Nephrology Terms and Conditions

Figure 4 Effects of Nw-nitro-L-arginine (L-NNA) and 14, 15-epoxyeicosa-5(Z)-enoic acid (14,15-EEZE), alone or in combination, on acetylcholine (ACh)-induced afferent arteriolar relaxation.*P < 0.05; **P < 0.01; ***P < 0.001 compared to control. aP < 0.05; bP < 0.001 compared to L-NNA alone. Symbols are (■) Control; (▴) L-NNA; (•) EEZE; (○) EEZE + L-NNA. Kidney International 2003 63, 2187-2193DOI: (10.1046/j.1523-1755.2003.00036.x) Copyright © 2003 International Society of Nephrology Terms and Conditions