Post-transplant hypophosphatemia: Tertiary ‘Hyper-Phosphatoninism’?

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Post-transplant hypophosphatemia: Tertiary ‘Hyper-Phosphatoninism’? I. Bhan, A. Shah, J. Holmes, T. Isakova, O. Gutierrez, S.-A. Burnett, H. Jüppner, M. Wolf Kidney International Volume 70, Issue 8, Pages 1486-1494 (October 2006) DOI: 10.1038/sj.ki.5001788 Copyright © 2006 International Society of Nephrology Terms and Conditions

Figure 1 Scatter plots for (a) serum creatinine, (b) potassium, (c) serum phosphate, (d) FEPO4, (e) FGF-23, (f) PTH, and (g) calcitriol plotted against the days post-transplant. Pre-transplant levels are plotted at time=0. The shaded area in (b, c, and f) represents the normal range of these variables. Kidney International 2006 70, 1486-1494DOI: (10.1038/sj.ki.5001788) Copyright © 2006 International Society of Nephrology Terms and Conditions

Figure 2 Pre- and first post-transplant (a) FGF-23 and (b) PTH levels in subjects who did or did not develop severe hypophosphatemia (≤1.5mg/dl). Individual subjects' levels are connected. (a) The RR of developing severe hypophosphatemia was 5.3 (P=0.02) among those whose area under the FGF-23 curve was greater than the median compared to those below the median. (b) The RR of developing severe hypophosphatemia was 0.2 (P=0.01) among those whose area under the PTH curve was greater than the median compared to those below the median. Kidney International 2006 70, 1486-1494DOI: (10.1038/sj.ki.5001788) Copyright © 2006 International Society of Nephrology Terms and Conditions