Volume 156, Issue 6, Pages 1693-1706.e12 (May 2019) Effects of Hypercholesterolemia and Statin Exposure on Survival in a Large National Cohort of Patients With Cirrhosis  David E. Kaplan, Marina A. Serper, Rajni Mehta, Rena Fox, Binu John, Ayse Aytaman, Michelle Baytarian, Kristel Hunt, Jeffrey Albrecht, Basile Njei, Tamar H. Taddei  Gastroenterology  Volume 156, Issue 6, Pages 1693-1706.e12 (May 2019) DOI: 10.1053/j.gastro.2019.01.026 Copyright © 2019 AGA Institute Terms and Conditions

Gastroenterology 2019 156, 1693-1706.e12DOI: (10.1053/j.gastro.2019.01.026) Copyright © 2019 AGA Institute Terms and Conditions

Figure 1 Unadjusted survival analyses for patient subgroups defined by exposure to lipid-lowering agents. (A) OS comparing existing users with statin-naïve subjects. (B) OS comparing existing users and statin-naïve subjects subdivided as new initiators and non-initiators. (C–D) As in (B), with CTP A or B class only. (E) Event-free survival for hepatic decompensation or HCC in CTP A class only and (F) MACEs in CTP A class only. HRs were generated by Cox proportional hazard models and P values were analyzed by log-rank test. Plots exclude incident events occurring within 180 days of follow-up. OS, overall survival. Gastroenterology 2019 156, 1693-1706.e12DOI: (10.1053/j.gastro.2019.01.026) Copyright © 2019 AGA Institute Terms and Conditions

Figure 2 Correlation of total cholesterol with parameters of hepatic function. Median, interquartile range, and 95% CIs (boxplots) across total cholesterol categories in statin-naïve patients of (A) platelet count and (B) serum albumin. Distribution of (C) CTP score and (D) MELDNa scores for each cholesterol quintile. (E) Boxplots showing distribution of total cholesterol levels across CTP classes. (F) Kaplan-Meier curves for overall survival across total cholesterol strata with P value by log-rank test. Gastroenterology 2019 156, 1693-1706.e12DOI: (10.1053/j.gastro.2019.01.026) Copyright © 2019 AGA Institute Terms and Conditions

Supplementary Figure 1 CONSORT Diagram of subjects included in the study. Gastroenterology 2019 156, 1693-1706.e12DOI: (10.1053/j.gastro.2019.01.026) Copyright © 2019 AGA Institute Terms and Conditions

Supplementary Figure 2 Distribution of Total Cholesterol values in Patients with Cirrhosis relative to Age-Matched Controls. Matched controls were white men aged 55-64 years from NCEP.44 Gastroenterology 2019 156, 1693-1706.e12DOI: (10.1053/j.gastro.2019.01.026) Copyright © 2019 AGA Institute Terms and Conditions

Supplementary Figure 3 Correlation of total cholesterol with parameters of hepatic function. Median, interquartile range and 95% confidence intervals (box-plots) across total cholesterol quantiles in Statin-Naïve patients of A. platelet count, and B. serum albumin. Distribution of C. Child-Turcotte-Pugh score for each cholesterol quintile. D. Kaplan-Meier curves for overall survival across total cholesterol quantile with p-value by log-rank test. Gastroenterology 2019 156, 1693-1706.e12DOI: (10.1053/j.gastro.2019.01.026) Copyright © 2019 AGA Institute Terms and Conditions

Supplementary Figure 4 Correlation of LDL cholesterol with parameters of hepatic function. Median, interquartile range and 95% confidence intervals (box-plots) across LDL cholesterol categories A, C. or quintiles B, D. in Statin-Naïve patients of platelet count and serum albumin. Distribution of Child-Turcotte-Pugh score across LDL E. categories cholesterol or F. quintiles. Kaplan-Meier curves for overall survival across total cholesterol strata F. or quintiles G. with p-value by log-rank test. Gastroenterology 2019 156, 1693-1706.e12DOI: (10.1053/j.gastro.2019.01.026) Copyright © 2019 AGA Institute Terms and Conditions