Spectrum of FGFR3 Mutations in Multiple Intraindividual Seborrheic Keratoses  Christian Hafner, Arndt Hartmann, Francisco X. Real, Ferdinand Hofstaedter, Michael Landthaler, Thomas Vogt  Journal of Investigative Dermatology  Volume 127, Issue 8, Pages 1883-1885 (August 2007) DOI: 10.1038/sj.jid.5700804 Copyright © 2007 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 1 FGFR3 mutations in multiple intraindividual seborrheic keratosis. (a) HT29 colon carcinoma cell line was used as control DNA showing a wild-type FGFR3 sequence. In SK D65, three different FGFR3 mutations were detected simultaneously: R248C (red peak), S373C (green peak), Y375C (blue peak). Although the used SNaPshot® multiplex assay is not strictly quantitative, the relatively low amplitudes of the mutation peaks compared with the amplitudes of the wild-type peaks suggest that these mutations may be present only in a portion of this SK rather than in the whole skin lesion. (b) Distribution of the different FGFR3 mutations in SK among the four analyzed patients. Journal of Investigative Dermatology 2007 127, 1883-1885DOI: (10.1038/sj.jid.5700804) Copyright © 2007 The Society for Investigative Dermatology, Inc Terms and Conditions