bHLH-PAS protein family structure and phylogeny.

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bHLH-PAS protein family structure and phylogeny. bHLH-PAS protein family structure and phylogeny. (A) bHLH-PAS protein domain schematic architecture in eukaryotes. Dotted line indicates possible absence of the second PAS in some Opisthokonta species; gray patterns represent the variations in N-terminal and C-terminal length in different groups. (B) Maximum likelihood (ML) phylogenetic tree of the bHLH-PAS family (outgroup: the Opisthokonta clade) midpoint rooted. Numbers refer to bootstrap values of the basal nodes using ML (RAxML, 1,000 bootstraps) and Bayesian inference (MrBayes). Symbols indicate the position of P. tricornutum RITMO1 and bHLH1b (arrows) and T. pseudonana bHLH1 (square). Rossella Annunziata et al. PNAS doi:10.1073/pnas.1819660116 ©2019 by National Academy of Sciences