Innate immune responses to rhinovirus are reduced by the high-affinity IgE receptor in allergic asthmatic children Sandy R. Durrani, MD, Daniel J. Montville,

Slides:

Advertisements

Similar presentations

Control of immunopathology during chikungunya virus infection Caroline Petitdemange, PhD, Nadia Wauquier, PhD, Vincent Vieillard, PhD Journal of Allergy.

Advertisements

Endoplasmic reticulum stress influences bronchial asthma pathogenesis by modulating nuclear factor κB activation So Ri Kim, MD, PhD, Dong Im Kim, MS, Mi.

Preseasonal treatment with either omalizumab or an inhaled corticosteroid boost to prevent fall asthma exacerbations Stephen J. Teach, MD, MPH, Michelle.

Peter Vadas, MD, PhD, Boris Perelman, PhD, Gary Liss, MD, MS

Pharmacologic rationale for treating allergic and nonallergic rhinitis

IgE cross-linking impairs monocyte antiviral responses and inhibits influenza-driven TH1 differentiation Regina K. Rowe, MD, PhD, David M. Pyle, MD,

Santa Jeremy Ono, BA, PhD, Mark B. Abelson, MD

Ann-Marie M. Schoos, MD, PhD, Jacob D

Differential cytokine induction by the human skin–associated autoallergen thioredoxin in sensitized patients with atopic dermatitis and healthy control.

Atopic dermatitis: Age and race do matter!

Major rabbit allergen Ory c 3: What could be its possible role as a sensitizing agent in real life? Gennaro Liccardi, MD, Antonello Salzillo, MD, Maria.

Robert F. Lemanske, MD, Daniel J. Jackson, MD, Ronald E

Is 9 more than 2 also in allergic airway inflammation?

Frederick J. Rubner, MD, Daniel J. Jackson, MD, Michael D

Robert G. Hamilton, PhD, John Oppenheimer, MD

Association of rhinovirus species with common cold and asthma symptoms and bacterial pathogens Hiba Bashir, MD, Kristine Grindle, BS, Rose Vrtis, BS,

Preseasonal treatment with either omalizumab or an inhaled corticosteroid boost to prevent fall asthma exacerbations Stephen J. Teach, MD, MPH, Michelle.

Keith J. Simons, PhD, Margherita Strolin Benedetti, PhD, F. Estelle R

Toll-like receptor 9 suppression in plasmacytoid dendritic cells after IgE-dependent activation is mediated by autocrine TNF-α John T. Schroeder, PhD,

Lieuwe D. Bos, MSc, PhD, Peter J. Sterk, MD, PhD, Stephen J

Detection of pathogenic bacteria during rhinovirus infection is associated with increased respiratory symptoms and asthma exacerbations Kirsten M. Kloepfer,

Allergy testing in predicting outcome of open food challenge to peanut

David M. Pyle, BS, Victoria S. Yang, MD, Rebecca S

Peter M. Wolfgram, MD, David B. Allen, MD

Daniel J. Jackson, MD, James E. Gern, MD, Robert F. Lemanske, MD

Jewlya Lynn, PhD, Sophie Oppenheimer, MS, MPH, Lorena Zimmer, MA

Biologics and biomarkers for asthma, urticaria, and nasal polyposis

IL-5 T-cell responses to house dust mite are associated with the development of allergen-specific IgE responses and asthma in the first 5 years of life

Time for a paradigm shift in asthma treatment: From relieving bronchospasm to controlling systemic inflammation Leif Bjermer, MD Journal of Allergy.

Food allergy: A review and update on epidemiology, pathogenesis, diagnosis, prevention, and management Scott H. Sicherer, MD, Hugh A. Sampson, MD Journal.

Biosimilars and drug development in allergic and immunologic diseases

Daphne Koinis-Mitchell, PhD, Timothy Craig, DO, Cynthia A

A cluster-randomized trial shows telephone peer coaching for parents reduces children's asthma morbidity Jane M. Garbutt, MB, ChB, Yan Yan, MD, PhD,

Peter Vadas, MD, PhD, Boris Perelman, PhD, Gary Liss, MD, MS

Claus Bachert, MD, PhD, Cezmi A. Akdis, MD

Update on the role of prostaglandins in allergic lung inflammation: Separating friends from foes, harder than you might think Martin L. Moore, PhD, R.

Cephalosporin Side Chain Cross-reactivity

Immune responses to mosquito saliva in 14 individuals with acute systemic allergic reactions to mosquito bites Zhikang Peng, MD, Andrew N. Beckett, BSc,

H. William Kelly, PharmD Journal of Allergy and Clinical Immunology

Cockroach allergens: Coping with challenging complexity

Autophagy: Nobel Prize 2016 and allergy and asthma research

Influence of early-life exposures on food sensitization and food allergy in an inner-city birth cohort Emily C. McGowan, MD, Gordon R. Bloomberg, MD,

A single intervention for cockroach control reduces cockroach exposure and asthma morbidity in children Felicia A. Rabito, PhD, MPH, John C. Carlson,

Mary F. Linehan, PhD, Timothy L. Frank, MD, Michelle L

Sara Paveglio, PhD, MS, Erin Bennett, MS, Kelly L. Hawley, PhD, Adam P

Comparison of rhinovirus antibody titers in children with asthma exacerbations and species-specific rhinovirus infection Jua Iwasaki, BSc (Hons), Wendy-Anne.

Fractional exhaled nitric oxide measurements are most closely associated with allergic sensitization in school-age children Daniel J. Jackson, MD, Christine.

One step forward, 2 steps back: The enigma of preschool wheeze

Anaphylaxis during anesthesia in France: An 8-year national survey

Bidirectional interactions between viral respiratory illnesses and cytokine responses in the first year of life James E. Gern, MD, G. Daniel Brooks,

Weekly monitoring of children with asthma for infections and illness during common cold seasons Jaime P. Olenec, MD, Woo Kyung Kim, MD, Wai-Ming Lee,

Halie M. Anderson, MD, Robert F. Lemanske, MD, Michael D

Risk of oral food challenges

Anne Marie Singh, MD, Michael D

Jessica H. Savage, MD, MHS, Elizabeth C. Matsui, MD, MHS, Robert A

Grass pollen immunotherapy: IL-10 induction and suppression of late responses precedes IgG4 inhibitory antibody activity James N. Francis, PhD, Louisa.

Usa Tantibhaedhyangkul, MD, Carla M. Davis, MD, Lenora M

Immune response to varicella vaccine in children with atopic dermatitis compared with nonatopic controls Lynda Schneider, MD, Adriana Weinberg, MD, Mark.

Edith Chen, PhD, Madeleine U. Shalowitz, MD, Rachel E

Macrolide antibiotics and asthma treatment

Innate immune defects correlate with failure of antibody responses to H1N1/09 vaccine in HIV-infected patients Suresh Pallikkuth, PhD, Sudheesh Pilakka.

Asthma: The past, future, environment, and costs

Julie Negri, BA, S. Brandon Early, BA, John W

Asthma Control Test: Reliability, validity, and responsiveness in patients not previously followed by asthma specialists Michael Schatz, MD, MS, Christine.

Combination treatment with omalizumab and rush immunotherapy for ragweed-induced allergic rhinitis: Inhibition of IgE-facilitated allergen binding Sven.

Advances in pediatric asthma in 2007

Natural history of cow’s milk allergy

The Editors’ Choice Journal of Allergy and Clinical Immunology

Primary prevention of asthma and allergy

Decreased lung function after preschool wheezing rhinovirus illnesses in children at risk to develop asthma Theresa W. Guilbert, MD, MS, Anne Marie Singh,

Presentation transcript:

Innate immune responses to rhinovirus are reduced by the high-affinity IgE receptor in allergic asthmatic children Sandy R. Durrani, MD, Daniel J. Montville, BS, Allison S. Pratt, MD, Sanjukta Sahu, MS, Mark K. DeVries, BS, Victoria Rajamanickam, MS, Ronald E. Gangnon, PhD, Michelle A. Gill, MD, PhD, James E. Gern, MD, Robert F. Lemanske, MD, Daniel J. Jackson, MD Journal of Allergy and Clinical Immunology Volume 130, Issue 2, Pages 489-495 (August 2012) DOI: 10.1016/j.jaci.2012.05.023 Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 A, Comparison of PBMC HRV-induced mean IFN-α production when pretreated with media (no pretreatment), 1 μg/mL rabbit IgG isotype control antibody, or 1 μg/mL anti-IgE for 2 hours. Pretreatment of PBMCs with 1 μg/mL anti-IgE to cross-link FcεRI resulted in significantly lower HRV-induced IFN-α production (mean ± SE: 750 ± 108 pg/mL) compared with pretreatment with 1 μg/mL rabbit IgG isotype control (1299 ± 141 pg/mL, P < .0001) or no pretreatment (1410 ± 150 pg/mL, P < .0001) n = 44. B, Comparison of PBMC HRV-induced mean IFN-λ1 production (in picograms per milliliter) when pretreated with media (no pretreatment), 1 μg/mL rabbit IgG isotype control antibody, or 1 μg/mL anti-IgE for 2 hours. Pretreatment of PBMCs with 1 μg/mL anti-IgE to cross-link FcεRI resulted in significantly decreased HRV-induced IFN-λ1 production (mean ± SE: 39 ± 9 pg/mL) compared with pretreatment with 1 μg/mL rabbit IgG isotype control (171 ± 31 pg/mL, P < .0001) or no pretreatment (206 ± 36 pg/mL, P < .0001) n = 44. Journal of Allergy and Clinical Immunology 2012 130, 489-495DOI: (10.1016/j.jaci.2012.05.023) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 A, Comparison of allergic asthmatic (n = 14), allergic nonasthmatic (n = 13), and nonallergic nonasthmatic (n = 14) children’s PBMC HRV-induced IFN-α production (in picograms per milliliter) after cross-linking FcεRI with 1 μg/mL anti-IgE for 2 hours before HRV stimulation. Allergic asthmatic children had significantly lower HRV-induced IFN-α production (mean ± SE: 366 ± 126 pg/mL) than both allergic nonasthmatic (1085 ± 261 pg/mL, P = .004) and nonallergic nonasthmatic (878 ± 159 pg/mL, P = .002) children. B, Comparison of allergic asthmatic (n = 14), allergic nonasthmatic (n = 13), and nonallergic nonasthmatic (n = 14) children's PBMC HRV-induced mean IFN-λ1 production (in picograms per milliliter) after cross-linking FcεRI with 1 μg/mL anti-IgE for 2 hours before HRV stimulation. Allergic asthmatic children had significantly lower HRV-induced IFN-λ1 production (mean ± SE: 16 ± 5 pg/mL) than both allergic nonasthmatic (62 ± 28 pg/mL, P = .02) and nonallergic nonasthmatic (42 ± 8 pg/mL, P = .01) children. Journal of Allergy and Clinical Immunology 2012 130, 489-495DOI: (10.1016/j.jaci.2012.05.023) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions