Volume 55, Issue 5, Pages (May 1999)

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Presentation transcript:

Volume 55, Issue 5, Pages 1983-1990 (May 1999) Histological characteristics of sternoclavicular β2-microglobulin amyloidosis and clues for its histogenesis Christian Garbar, Michel Jadoul, Henri Noël, Charles van Ypersele de Strihou Kidney International Volume 55, Issue 5, Pages 1983-1990 (May 1999) DOI: 10.1046/j.1523-1755.1999.00430.x Copyright © 1999 International Society of Nephrology Terms and Conditions

Figure 1 Small cartilaginous Aβ2m deposits (arrowheads;A and B) and massive cartilaginous Aβ2m deposits (C and D); anti-β2m immunoperoxidase (left) and anti-CD68 immunoperoxidase (right). There is an absence of macrophagic infiltration (magnification ×250). Kidney International 1999 55, 1983-1990DOI: (10.1046/j.1523-1755.1999.00430.x) Copyright © 1999 International Society of Nephrology Terms and Conditions

Figure 2 Large capsular Aβ2m deposits (arrowheads) without macrophagic infiltration (A and B) and synovial Aβ2m deposits (arrowheads) with macrophages (arrows) in the vicinity (C and D); anti-β2m immunoperoxidase (left) and anti-CD68 immunoperoxidase (right). (Magnification ×400.) Kidney International 1999 55, 1983-1990DOI: (10.1046/j.1523-1755.1999.00430.x) Copyright © 1999 International Society of Nephrology Terms and Conditions

Figure 3 Marginal bone erosion delineated by the arrowheads. Large Aβ2m deposits are present in the cartilage (arrows) and small Aβ2m deposits within the erosion (Congo Red, magnification ×20). C, capsule. Kidney International 1999 55, 1983-1990DOI: (10.1046/j.1523-1755.1999.00430.x) Copyright © 1999 International Society of Nephrology Terms and Conditions

Figure 4 Schematic representation of the three stages of Aβ2m deposition. Aβ2m is represented in black (bone A, cartilage B, capsule C, synovium D). Macrophages accumulate around synovial Aβ2m in stage III. Kidney International 1999 55, 1983-1990DOI: (10.1046/j.1523-1755.1999.00430.x) Copyright © 1999 International Society of Nephrology Terms and Conditions