Visualization of differential changes between chronic versus acute PDGFRα stimulation. Visualization of differential changes between chronic versus acute.

Slides:

Advertisements

Similar presentations

Gene Regulatory Networks - the Boolean Approach Andrey Zhdanov Based on the papers by Tatsuya Akutsu et al and others.

Advertisements

2.7 DNA Replication, transcription and translation

Ribosome Structure 1. Outline the structure of a ribosome based on the diagram: ● A site.

JAK-STAT Signaling Pathway.

Topic 1-5 Angle Relationships.

10-3 Protein Synthesis Together, all 3 types of RNA synthesize proteins. Proteins are polymers. Polypeptides linked by peptide bonds. Made of 20 different.

Translation 2.7 & 7.3.

binding sites 58 of the 473 unambiguously assigned phosphorylation sites are predicted by Scansite to be sites for binding. 50 of these correspond.

Crystal Structure of Glycogen Synthase Kinase 3β

Network of Twitter interactions.

Posttranslational regulation of self-renewal capacity: insights from proteome and phosphoproteome analyses of stem cell leukemia by Matthias Trost, Martin.

Distribution of disorder in the cytosolic phosphoproteome

NSAF and GeneChip datasets have a similar variance-versus-mean dependence.A–C, the rowMean and the rowS.D. of the abundance values for each transcript.

Comparative analysis of RNA and protein profiles.

A Wiring of the Human Nucleolus

Figure 4 Immune regulatory roles of glycolytic intermediates

IRS1-Independent Defects Define Major Nodes of Insulin Resistance

PDGFRα GBM primary cultures demonstrate titratable and temporal DOX-inducible expression of hPDGF-A and receptor activation. PDGFRα GBM primary cultures.

Volume 18, Issue 12, Pages (December 2011)

Analysis of total and polysomal RNA clk-1(qm30) and clk-1(qm30)+WT.

Sequencing at 10,000x using Illumina paired reads

Volume 6, Issue 6, Pages (December 2000)

INDRA Statements constructed from TRIPS NLP extractions, BioPAX, and BEL INDRA Statements constructed from TRIPS NLP extractions, BioPAX, and BEL An identical.

Multiplying Messages LRRK beneath Parkinson Disease

_____ _____ are _____ by _____ ____ sequences.

MicroRNAs: From Decay to Decoy

Ashton Breitkreutz, Lorrie Boucher, Mike Tyers Current Biology

Dynamic changes of protein phosphorylation identify ERK1/2 substrates from cytosolic and nuclear compartments. Dynamic changes of protein phosphorylation.

Time course of phosphorylation changes at Ser-293, Ser-300, and Ser-232 in PDHE1α following kinase inhibition with DCA. A, relative quantitation over three.

Genome-wide analysis of p53 occupancy.

Schematic summarizing the various functions and features of MASH Suite Pro. Schematic summarizing the various functions and features of MASH Suite Pro.

Differential relative abundance of major taxa for successive pairwise comparisons. Differential relative abundance of major taxa for successive pairwise.

Volume 39, Issue 2, Pages (October 2016)

Neurogenins induce a network of transcription factors that mediate iNGN neurogenesisA network of transcription factors involved in iNGN neurogenesis was.

Crystal Structure of Glycogen Synthase Kinase 3β

Molecular mechanism of STING-mediated inhibition of the mTORC1 pathway

The Dynamic Landscapes of RNA Architecture

Kinome‐wide activity regulation derived from known substrates and 41 quantitative phosphoproteomic studies Kinome‐wide activity regulation derived from.

Functional networks of proteins associated with SL3a, SL3abc, SL123, and D3 transcripts. Functional networks of proteins associated with SL3a, SL3abc,

qRT-PCR validation of differential expression.

Log- to stationary-phase growth results in differential acetyl abundance on specific proteins. Log- to stationary-phase growth results in differential.

2-D gel images visualized by Coomassie Brilliant Blue staining representing total proteins extracted from HCT-8 under apoptotic conditions in 2 mm Gln.

Structural mapping of the PLX3397-resistant mutations in FLT3.

Comparison of N. gonorrhoeae gene expression in infected men in vivo and isolates grown in vitro. Comparison of N. gonorrhoeae gene expression in infected.

X Y Relation (a set of ordered pairs) x y x y ( , ) x y Mapping

Individuals (dots) colored according to results of hierarchical clustering of copy number estimates (as described in Supplementary Text) for IGHV

Well characterized dsRNA substrates contain G–C pairs at a helical shift suitable for Stau binding. Well characterized dsRNA substrates contain G–C pairs.

PDGFRα activity reduces phosphorylation of critical members of the translational initiation complex. PDGFRα activity reduces phosphorylation of critical.

Model of translational regulation by PDGFRα.

MAGs and testes transcript expression levels in the An. gambiae complex. MAGs and testes transcript expression levels in the An. gambiae complex. (A) Percentage.

Activity flow of PDGFR signaling pathways.

PDGFRββ comprehensive map.

Thrombin activates MAPKAP2 kinase in vascular smooth muscle

Distribution of phosphosites and PDGFRα activity in primary cultures.

Statistics of cleavage sites and mutant-enriched sites.

Summary of RNA FISH quantifications.

TSA induces transcription from CCND1-MS2 alleles under CCND1 promoter control. TSA induces transcription from CCND1-MS2 alleles under CCND1 promoter control.

Three-dimensional vortical structure visualized by the iso-surfaces of the q criterion for inviscid (left column) and viscous (Re=4000) (middle column)

Chronic PDGFRα activation reduces sensitivity of PDGFRα-positive GBM cells to translational inhibitor–induced suppression on cell viability. Chronic PDGFRα.

Volume 15, Issue 2, Pages (April 2016)

Figure 1 bvFTD PINBPA network

Phospho-proteomic analysis of acutely and chronically stimulated PDGFRα signaling. Phospho-proteomic analysis of acutely and chronically stimulated PDGFRα.

Tumor phenotyping. Tumor phenotyping. (A) Comparative growth behavior of tumors after grafting R versus VR J2A, H1, and I1 cell lines in independent experiments.

(a) Molecular network clusters of pheophytin and procyanidin and their related metabolites. (a) Molecular network clusters of pheophytin and procyanidin.

The MS/MS spectra and MALDI IMS distributions of mannitol and the corresponding polysaccharide containing mannitol are shown. The MS/MS spectra and MALDI.

Fig. 5. Behaviours of the wild-types Oregon-R at two temperatures.

Distribution of patients in the first- or second-year follow-up according to the number of acute exacerbations of chronic obstructive pulmonary disease.

* Supplementary Fig. 1 (Yamanaka et al.) * * * ** ** ** * * **

Fig. 2 Visualization of features.

In silico, in vitro, and pharmacokinetic evaluation of the synthesized SANs. A, docking for sunitinib and SAN1–5 with estimated inhibition constants (Ki.

Presentation transcript:

Visualization of differential changes between chronic versus acute PDGFRα stimulation. Visualization of differential changes between chronic versus acute PDGFRα stimulation. (A) Cytoscape output of kinase–substrate network visualization of acute and chronic stimulation of PDGFRα. Source data were obtained by extracting kinase–substrate pairs from the PDGFRα MS data based on the Kinase_Substrate_Dataset. Phosphorylation sites were classified according to their molecular functions and assigned color codes that are consistent with those in Fig 2. The color of the edges represents the quantitative log2FC values from the MS data of stimulated to control unstimulated. (B) Close-up view of the most inhibited molecules and corresponding kinases in the category of “RNA binding and translation.” The Cytoscape format file of the network visualization is available in the Supplementary Information. Shuang Zhou et al. LSA 2018;1:e201800029 © 2018 zhou et al.