Volume 70, Issue 11, Pages (December 2006)

Slides:

Advertisements

Similar presentations

Pathways involved in oxalate, glyoxylate, and glycolate metabolism in the human hepatocyte. Peroxisomal enzymes: (1) L-2-hydroxy acid oxidase A/glycolate.

Advertisements

Epoetin use and Kidney Disease Outcomes Quality Initiative hemoglobin targets in patients returning to dialysis with failed renal transplants C.A. Solid,

Beta blockers in the management of chronic kidney disease

Volume 69, Issue 5, Pages (March 2006)

S.J. Nessim, S.V. Jassal, S.V. Fung, C.T. Chan Kidney International

Volume 67, Issue 1, Pages (January 2005)

Bettina Haslinger-Löffler Kidney International

Volume 71, Issue 11, Pages (June 2007)

The case ∣ A young woman with abdominal discomfort and a mass

Volume 77, Issue 5, Pages (March 2010)

Shining light on vitamin D trials in chronic kidney disease

Volume 58, Issue 1, Pages (July 2000)

Evaluation of mutation screening as a first line test for the diagnosis of the primary hyperoxalurias1 Gill Rumsby, Emma Williams, Marion Coulter-Mackie

Volume 71, Issue 8, Pages (April 2007)

End-stage renal failure from asymptomatic bilateral ureteric stones

Volume 70, Pages S21-S25 (December 2006)

Long-neglected stent in a transplanted kidney

A new era in the treatment of calcium oxalate stones?

Kidney International in 2007: Celebrating new features

Volume 86, Issue 6, Pages (December 2014)

D. Batlle, P. Ramadugu, M.J. Soler Kidney International

Volume 70, Issue 11, Pages (December 2006)

J. Himmelfarb, T.A. Ikizler Kidney International

S.J. Nessim, S.V. Jassal, S.V. Fung, C.T. Chan Kidney International

Volume 71, Issue 11, Pages (June 2007)

Nephrology Crosswords: Hemodialysis

Volume 71, Issue 11, Pages (June 2007)

Acute oxalate nephropathy due to ethylene glycol ingestion

Arginase in glomerulonephritis

Volume 71, Issue 6, Pages (March 2007)

Volume 70, Issue 12, Pages (December 2006)

Blood pressure targets in hemodialysis patients

Fructose intake as a risk factor for kidney stone disease

The third World Kidney Day: Looking back and thinking forward

Volume 72, Issue 1, Pages 8-10 (July 2007)

Volume 69, Issue 12, Pages (June 2006)

Volume 69, Issue 3, Pages (February 2006)

Microbiology and outcomes of peritonitis in North America

AGEs in foods: Do they play a role in uremia?

Yin and Yang: The Dao of the kidney

The global challenge of chronic kidney disease

Nephrology Crossword: Glomerulonephritis

Volume 69, Issue 8, Pages (April 2006)

Plasma calcium-oxalate saturation in children with renal insufficiency and in children with primary hyperoxaluria Bernd Hoppe, Markus J. Kemper, Arend.

Volume 71, Issue 4, Pages (February 2007)

Volume 71, Issue 4, Pages (February 2007)

Fibroblast growth factor 23: the making of a hormone

Mediterranean diets: are they practical in the Western world?

Volume 71, Issue 11, Pages (June 2007)

The valuable contribution of observational studies to nephrology

Epoetin use and Kidney Disease Outcomes Quality Initiative hemoglobin targets in patients returning to dialysis with failed renal transplants C.A. Solid,

Organ transplantation goes to the movies

Volume 72, Issue 2, Pages (July 2007)

Volume 62, Issue 2, Pages (August 2002)

Is it the low-protein diet or simply the salt restriction?

Treatment of the primary hyperoxalurias: A new chapter

Volume 59, Issue 6, Pages (June 2001)

Volume 70, Issue 3, Pages (August 2006)

Is complement a target for therapy in renal disease?

Urinalysis in Western culture: A brief history

Volume 70, Issue 3, Pages (August 2006)

Volume 71, Issue 9, Pages (May 2007)

Volume 70, Issue 5, Pages (September 2006)

The arrow of bioimpedance

Volume 72, Issue 11, Pages (December 2007)

Volume 70, Issue 10, Pages (November 2006)

The International Pediatric Peritonitis Registry: Starting to walk

In chronic kidney disease staging the use of the chronicity criterion affects prognosis and the rate of progression B.O. Eriksen, O.C. Ingebretsen Kidney.

Volume 72, Issue 12, (December 2007)

Hydroxyproline ingestion and urinary oxalate and glycolate excretion

Presentation transcript:

Volume 70, Issue 11, Pages 1891-1893 (December 2006) 4-Hydroxyproline metabolism and glyoxylate production: A target for substrate depletion in primary hyperoxaluria? M.B. Coulter-Mackie Kidney International Volume 70, Issue 11, Pages 1891-1893 (December 2006) DOI: 10.1038/sj.ki.5001987 Copyright © 2006 International Society of Nephrology Terms and Conditions

Figure 1 Simplified metabolic pathways leading to glyoxylate and oxalate. This figure outlines the major reactions under discussion, their subcellular locations, and potential sites for intervention to achieve substrate (glyoxylate) depletion. AGT, alanine:glyoxylate aminotransferase; DAO, D-amino acid oxidase; GO, glycolate oxidase; GR, glyoxylate reductase; LDH, lactate dehydrogenase; HKGA, 4-hydroxy-2-ketoglutarate lyase. Solid arrows: enzymatic reactions; broken arrows: transport: proposed sites for intervention. Kidney International 2006 70, 1891-1893DOI: (10.1038/sj.ki.5001987) Copyright © 2006 International Society of Nephrology Terms and Conditions