Temporal-Spatial Gait Characteristics in Youths with Hypermobile Ehlers-Danlos By: Nicole Vigon.

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Temporal-Spatial Gait Characteristics in Youths with Hypermobile Ehlers-Danlos By: Nicole Vigon

Quantify temporal-spatial parameters of gait in youths with HEDS Goal Quantify temporal-spatial parameters of gait in youths with HEDS

Introduction hEDS is a disorder that affects connective tissues [1] Primarily skin, joints and blood vessel walls 1 in 5000 individuals have hEDS [2] Symptoms include overly flexible joints that can dislocate Creating joint instability leading to early-onset osteoarthritis [6] Study of gait parameters developed for adults [3] Currently a lack of knowledge on the effect of these symptoms on the gait of youths with hEDS

Methods

Subjects Five (5) children with hEDS Two males and three females Mean age of 14.6 (2.6) years old Mean height: 153.64 (22.33) cm Mean weight: 57.5 (10.37) kg

Data Collection (Fig. 1) 15 camera Vicon MX system: 120 Hz Task: Gait at self-selected, fast and slow- pace Data Processing 5 gait cycles per subject analyzed Gait cycle divisions identified by: Heel strike (HS) and toe off (TO) allows walking trials to be broken up into gait cycles consisting of a stance and swing phase

Results Speed Stride Length (m) Cadence (strides/min) Walking Speed (m/s) Percent of gait cycle in single leg support (%) Percent of gait cycle in initial double support (%) Self- Selected 1.40 (0.05) 57.31 (1.86) 1.34 (0.08) 39.74 (1.99) 19.59 (1.68) Fast 1.68 (0.09) 75.64 (3.82) 2.11 (0.16) 42.21 (1.64) 14.71 (2.38) Slow 1.31 (0.05) 40.26 (3.68) 0.88 (0.09) 34.56 (2.23) 31.65 (3.30)

Discussion When compared to healthy gait the averages of youths with hEDS fell within normal ranges The motion analysis methods effectively characterized temporal-spatial parameters in youths with hEDS Investigation in a larger population is ongoing to characterize the temporal-spatial parameters in youths with hEDS

Conclusion Identification of differences between those with hEDS and healthy individuals may provide insight to the development of pain and injury increase over time. With this knowledge physical therapists may be able to work with hEDS patients to effectively decrease their risk of early-onset osteoarthritis.

References Acknowledgments Beighton P, et al. Ehlers-Danlos Syndromes, 77:31-37, 1998. Tinkle B, et al. Hypermobile Ehlers-Danlos Syndrome 175C:48-69, 2017. Rombaut, L, et al. Balance, Gait, Falls, and Fear of Falling in Women With the Hypermobility Type of Ehlers-Danlos Syndrome 1432–1439, 2011. Sutherland et al. Normal Gait 1988 Whittle Gait Analysis 1990 Pepin, Melanie, et al. "Clinical and genetic features of Ehlers–Danlos syndrome type IV, the vascular type." New England Journal of Medicine 342.10 (2000): 673-680 Supported by the Genetic Center of the Children's Hospital of Wisconsin. A special thanks to the Stimulus Package to Accelerate Research Clusters (SPARC) grant and the Support of Undergraduate Research Fellows (SURF) grant.

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