Volume 63, Issue 1, Pages 315-322 (January 2003) Impact of albumin synthesis rate and the acute phase response in the dual regulation of fibrinogen levels in hemodialysis patients1  George A. Kaysen, Joel A. Dubin, Hans-Georg Müller, William E. Mitch, Laura Rosales, Nathan W. Levin  Kidney International  Volume 63, Issue 1, Pages 315-322 (January 2003) DOI: 10.1046/j.1523-1755.2003.00721.x Copyright © 2003 International Society of Nephrology Terms and Conditions

Figure 1 (A) Relationship between plasma fibrinogen concentration and C-reactive protein (CRP) level following log transformation (R = 0.272;P = 0.22). (B) Relationship between plasma fibrinogen concentration and ceruloplasmin during the baseline cross-sectional measurement (R = 0.317; P = 0.007). Kidney International 2003 63, 315-322DOI: (10.1046/j.1523-1755.2003.00721.x) Copyright © 2003 International Society of Nephrology Terms and Conditions

Figure 2 Relationship between plasma fibrinogen concentration and plasma volume (% body weight) during baseline cross sectional measurement (R = 0.516;P< 0.001). Kidney International 2003 63, 315-322DOI: (10.1046/j.1523-1755.2003.00721.x) Copyright © 2003 International Society of Nephrology Terms and Conditions

Figure 3 Relationship between plasma fibrinogen concentration and both albumin synthesis in g/1.73m2/day and plasma volume in percent body weight (PV%) at the time of the initial injection of [125]I albumin. Fibrinogen = 603 + (13.14 * albumin synthesis/1.73m2) -[52.67 * PV(%)]; PV, P < 0.0001, r2 = 0.1984; albumin synthesis, P < 0.0001, r2 = 0.1586. Kidney International 2003 63, 315-322DOI: (10.1046/j.1523-1755.2003.00721.x) Copyright © 2003 International Society of Nephrology Terms and Conditions

Figure 4 Temporal variation in serum fibrinogen concentration (•; weeks vs. fibrinogen g/L), CRP concentration (▵; weeks vs. CRP mg/dL), albumin (□·; weeks vs. albumin g/dL) and α1 acid glycoprotein (⋄; weeks vs α1 AG g/L) in four consecutive hemodialysis patients in whom CRP changed by at least one order of magnitude during the period of observation. Units were scaled to show protein levels in similar ranges. Kidney International 2003 63, 315-322DOI: (10.1046/j.1523-1755.2003.00721.x) Copyright © 2003 International Society of Nephrology Terms and Conditions

Figure 5 Box plots of coefficients of variation (standard deviation divided by mean) of albumin (Alb), transferrin (Trf), C-reactive protein (CRP) α1 acid glycoprotein (α1 AG), ceruloplasmin (Cer), interleukin 6 (IL-6) and fibrinogen (Fib) during sequential measurements in 74 patients on hemodialysis ranging from 3.25 to 67.5 months.*P < 0.05 vs. albumin; +P < 0.05 vs. CRP and IL-6. Kidney International 2003 63, 315-322DOI: (10.1046/j.1523-1755.2003.00721.x) Copyright © 2003 International Society of Nephrology Terms and Conditions