Figure 2 SORL1 mutants' overexpression increases β-amyloid secretion

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Date of download: 9/17/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Reduction of SorLA/LR11, a Sorting Protein Limiting.

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Figure S1. Generation of AD/PNGFP+/+ Mice

Figure 4 K19del mutation alters CHP1 association into functional complexes, impairs NHE1 membrane targeting, and potentially compromises protein conformational.

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Figure 2 GlyR antibody binding

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Fig. 2 Fas controls IL-1RA–sEV secretion in murine MSCs.

Volume 10, Issue 3, Pages (March 2018)

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Figure 3 Voltage-clamp recording of the wild-type KCNJ18 (left) and the KCNJ18 carrying the patient's SNVs (right) expressed in Xenopus laevis oocytes.

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Figure 5 ADP-induced inflammatory responses require P2Y12 receptors in human microgliaIncreasing concentrations of ADP (5, 50, and 200 μM) increased tumor.

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Figure 4 ADP-induced migration of human microglia is blocked by a P2Y12 antagonist(A) Using 10 μm cell migration chambers followed by crystal violet staining,

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Figure 2 Immunoblotting of erythrocyte membranes, lymphoblastoid cells, and co-immunoprecipitants Immunoblotting of erythrocyte membranes, lymphoblastoid.

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Figure 2 Antibodies to MOG detected with anti-human IgG (H + L) as the secondary antibody(A) Schematic of the human MOG proteins tested. Antibodies to.

Figure 2 LMNB1 mRNA expression

Figure 3 Within-group comparisons (before–after)‏

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Haisun Zhu, Carla B. Green Current Biology

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Fig. 5 C9orf72 knockdown disrupts autophagy induction.

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Fig. 6 The C9ORF72/SMCR8 complex regulates ULK1.

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Kros of Single grf Knockout Mutants.

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Figure 2 SORL1 mutants' overexpression increases β-amyloid secretion SORL1 mutants' overexpression increases β-amyloid secretion (A–C) Secreted β-amyloid 40 (Aβ40), Aβ42, and amyloid precursor protein soluble β-secretase (APPsβ) were measured from culture medium in stable HEK293 cells expressing the APP Swedish mutant (HEKsw) together with either wild-type SORL1 or mutant SORL1. Error bars represent standard error of the mean (SEM). ***p < 0.001, *p < 0.05, ns, not significant, n = 3 independent replications. (D) Western blot was performed to detect APP soluble α-secretase (APPsα) from cultured media. Bar graphs were normalized to control. **p < 0.01, n = 3 independent replications, and error bars represent the SEM. Aβ = β-amyloid; FL-APP = full-length APP; SORL1 = sortilin-related receptor. Michael L. Cuccaro et al. Neurol Genet 2016;2:e116 © 2016 American Academy of Neurology