Correlation of DNMT3A expression and its variants with clinical parameters. Correlation of DNMT3A expression and its variants with clinical parameters.

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Correlation of DNMT3A expression and its variants with clinical parameters. Correlation of DNMT3A expression and its variants with clinical parameters. Gene expression analysis was performed using the RNA–seq data of 107 AML patients from the TCGA repository. (A) Overall, DNMT3A expression correlated with the M4 group of the French–American–British classification and (B) with the intermediate cytogenetic risk group. Correlation of the DNMT3A transcript-specific exons (C)DNMT3A1-exon (ENSE00001486208) and (D)DNMT3A2-exon (ENSE00001486123) with cytogenetic risk groups. Statistical significance was estimated with the Mann–Whitney test. *P < 0.05, **P < 0.01, ***P < 0.001. Tanja Božić et al. LSA 2018;1:e201800153 © 2018 Božić et al.