a b Supplementary Figure 1 Plasma Vosaroxin (ng/mL) Time (h)

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a b Supplementary Figure 1 Plasma Vosaroxin (ng/mL) Time (h) 20 40 60 80 100 120 140 1 10 1000 10000 18 mg/m 2 n=3 27 mg/m n=6 38 mg/m 50 mg/m n=8 60 mg/m n=4 72 mg/m n=11 90 mg/m Plasma Vosaroxin (ng/mL) 50 150 200 250 300 350 a b Supplementary Figure 1 Leukemia manuscript KF10-LEU-1089RRR Supplemental Figure 1 Figure 1. Average concentration-time plots by vosaroxin treatment schedule and group in cycle 1. (a), weekly schedule; (b), twice weekly schedule; h, hours. Error bars represent standard error of the mean.