Activity of TP-271 administered i. v. and p. o Activity of TP-271 administered i.v. and p.o. in a neutropenic murine MRSA tet(M) pneumonia model. Activity of TP-271 administered i.v. and p.o. in a neutropenic murine MRSA tet(M) pneumonia model. Each symbol represents an individual mouse, and horizontal lines indicate the means. (A) TP-271 IV (i.v. administration). Untreated controls at 0 and 24 h, relative to the start of treatment, closed circles; TP-271, 1 mg/kg (1 mpk) (open triangles), 5 mg/kg (gray triangles), and 10 mg/kg (closed triangles); linezolid, 10 mg/kg (closed squares). (B) TP-271 PO (p.o. administration). Untreated controls at 0 and 24 h, relative to the start of treatment, closed circles; TP-271, 12.5 mg/kg (open triangles), 25 mg/kg (light gray triangles), 50 mg/kg (dark gray triangles), and 100 mg/kg (closed triangles); linezolid, 10 mg/kg (open squares), 15 mg/kg (light gray squares), 30 mg/kg (dark gray squares), and 60 mg/kg (closed squares). Trudy H. Grossman et al. mSphere 2017; doi:10.1128/mSphere.00004-17