Supplementary Figure S1 B. Day 1 4 8 11 15 18 22 25 29 EOS SGI+CDDP biweekly Day 1 2 3 4 5 8 EOS SGI CDDP QD5 Day -3 1 4 8 11 15 22 EOS Day -3 1 2 3 4 5 8 EOS SGI CDDP

Supplementary Figure S2 B. C.

Supplementary Figure S3 (B). Parental A2780 cells, A2780-CDDP resistant cells, and CP70-CDDP resistant cells were treated with 5μM SGI-110 for 48 hours, and DNAs were extracted for pyrosequencing analysis for specific genes.

Supplementary Figure S4

Supplementary Figure S5 0 0.1 0.3 1 0.1 0.3 [SGI110] µM Day 4 Day 7 MLH1 Actin A2780 B. Day 7 0 0.1 0.3 1 0.1 0.3 1 [SGI110] µM Day 4 OAW28 MLH1 Actin Day 4 0 0.1 0.3 1 0 0.3 1 [SGI110] µM Day 6 OVCAR8 MLH1 Actin

Supplementary Figure S6

Supplementary Figure S7 B. QD5 Biweekly

Supplementary Figure S8 B.

Supplementary Figure S9 A. B. QD5 Biweekly C. D. QD5 Biweekly

Supplementary Figure S10 * QD5 A. B. * Biweekly

Supplementary Figure S11 B.