Over production of FAM134B-2 and disrupted FAM134B-2 mediated ER-phagy

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Hepatic FAM134B-2 is located in the SER and RER and degraded in the lysosome. Hepatic FAM134B-2 is located in the SER and RER and degraded in the lysosome.

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Over production of FAM134B-2 and disrupted FAM134B-2 mediated ER-phagy. Over production of FAM134B-2 and disrupted FAM134B-2 mediated ER-phagy. (A, B) qRT-PCR analysis (A) and immunoblot analysis (B) of FAM134B-2 in mouse primary hepatocytes. Mouse primary hepatocytes were isolated and cultured for the indicated time period. (C) Immunoblot analysis of FAM134B-2 and LC3B in mouse primary hepatocytes. Mouse primary hepatocytes were cultured in EBSS with or without bafilomycin A1 for 8 h. One-way ANOVA with a Student-Newman post-hoc test was used for statistical analysis. *P < 0.05. Shohei Kohno et al. LSA 2019;2:e201900340 © 2019 Kohno et al.