FGFR functions as a Pi sensor in vivo.

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FGFR functions as a Pi sensor in vivo. FGFR functions as a Pi sensor in vivo. (A) Schema of the experimental procedure. (B–D) Serum Pi, FEPi (B), serum Ca, FECa, serum urea nitrogen, serum creatinine (C), and serum full-length FGF23 (D) in mice fed a CP or HP diet for 2 wk under the administration of NVP-BGJ398. (E) Galnt3 mRNA expression in the femurs of mice fed a CP or HP diet for 2 wk under the administration of NVP-BGJ398 was evaluated by qPCR. Data represent the mean ± SEM. (B–E) n = 4 mice per group; *P < 0.05 by Student’s t test; NS, not significant. Yuichi Takashi et al. PNAS 2019;116:23:11418-11427 ©2019 by National Academy of Sciences