2/A Comparison of IP-10 and SIGLEC1 levels in healthy donors (HD), patients with glandular (gl.) and extraglandular (egl.) pSS and SLE 2/A. 2/A Comparison.

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Presentation transcript:

2/A Comparison of IP-10 and SIGLEC1 levels in healthy donors (HD), patients with glandular (gl.) and extraglandular (egl.) pSS and SLE 2/A. 2/A Comparison of IP-10 and SIGLEC1 levels in healthy donors (HD), patients with glandular (gl.) and extraglandular (egl.) pSS and SLE 2/A. (MWU statistics was used to test for differences). 2/B. Subsequent analysis of pSS subgroups without medication (using MWU test). 2/C.Correlation analysis (using SRT) between disease activity (ESSDAI) of patients with pSS, SIGLEC1 expression (MFI) on monocytes and IP-10 in sera were performed. Red dots refer to patients with documented egl. manifestation, while black dots refer to patients suffering from gl. manifestation only. Dashed lines show calculated thresholds of SIGLEC1 and IP-10. 2/D. Comparison of SIGLEC1 expressions and levels of IP-10 in mild versus moderate to high disease activity. ESSDAI, EULAR Sjögren's syndrome disease activity index; MFI, median fluorescence intensity; MWU, Mann Whitney U Test; no med., no medication; ns, not significant; p values *, p<0.05; **, p<0.01; ***, p<0.001; ****, p<0.0001; r, correlation coefficient; SIGLEC1, sialic acid binding Ig like lectin 1; SRT, Spearman rank test. Thomas Rose et al. RMD Open 2016;2:e000292 Copyright © BMJ Publishing Group & EULAR. All rights reserved.