Mean C-to-U editing ratios for most editing sites map to a region on chromosome 6 at 122 Mb. (A) Genome scan of mean C-to-U editing for 70 editing sites.

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Mean C-to-U editing ratios for most editing sites map to a region on chromosome 6 at 122 Mb. (A) Genome scan of mean C-to-U editing for 70 editing sites shows a strong association on chromosome 6. Mean C-to-U editing ratios for most editing sites map to a region on chromosome 6 at 122 Mb. (A) Genome scan of mean C-to-U editing for 70 editing sites shows a strong association on chromosome 6. Horizontal axis shows the mouse genome; vertical axis plots the LOD score. Red line is the permutation-derived α = 0.05 significance threshold. (B) Founder allele effects on chromosome 6 reveal a complex pattern of allele effects. Horizontal axis shows chromosome 6 in Mb. Vertical axis shows the founder allele effects. Tongjun Gu et al. Genetics 2015;202:787-798 Copyright © 2016 by the Genetics Society of America