Regulation of the G1/S transition phase in mesangial cells by E2F1

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Presentation transcript:

Regulation of the G1/S transition phase in mesangial cells by E2F1 Seiji Inoshita, Yoshio Terada, Osamu Nakashima, Michio Kuwahara, Sei Sasaki, Fumiaki Marumo Kidney International Volume 56, Issue 4, Pages 1238-1241 (October 1999) DOI: 10.1046/j.1523-1755.1999.00705.x Copyright © 1999 International Society of Nephrology Terms and Conditions

Figure 1 Schematic of the mechanisms of the G1/S transition phase. Growth factor signals are followed by various intracellular signaling pathways that increase the activity of cyclin D/CDK4 or CDK6 complexes. Cyclin D/CDK complexes facilitate phosphorylation of the Rb protein family with the release of E2F. Then, E2F increases the expression of genes required for the G1/S transition phase, including cyclin D1 and cyclin E. These cyclins also promote the phosphorylation of Rb protein and form an autoregulatory loop. Kidney International 1999 56, 1238-1241DOI: (10.1046/j.1523-1755.1999.00705.x) Copyright © 1999 International Society of Nephrology Terms and Conditions