Figure 3 Pedigrees of 3 multiplex families with NLRP3 mutations and MS The patient numbers refer to the patients listed in table 1. Pedigrees of 3 multiplex.

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Figure 3 Pedigrees of 3 multiplex families with NLRP3 mutations and MS The patient numbers refer to the patients listed in table 1. Pedigrees of 3 multiplex families with NLRP3 mutations and MS The patient numbers refer to the patients listed in table 1. The respective cryopyrin/NLRP3 mutations are indicated. Patients with clinically proven cryopyrin-associated periodic syndromes (CAPS) and multiple sclerosis (MS) are represented by filled black symbols; patients with only CAPS are shown by dark blue symbols; patients with MS without CAPS symptoms are represented by light blue symbols. * = positive history for symptoms compatible with CAPS; +/+ = homozygous, +/− = heterozygous. Elisabeth Schuh et al. Neurol Neuroimmunol Neuroinflamm 2015;2:e109 © 2015 American Academy of Neurology