Pathways involved in regulation of macrophage iNOS synthesis and NO production in response to H. pylori. Pathways involved in regulation of macrophage.

Slides:



Advertisements
Similar presentations
1 Helicobacter pylori arginase inhibits nitric oxide production by eukaryotic cells: A strategy for bacterial survival PNAS November 20, 2001 vol. 98 no.
Advertisements

Innate Immunity: The Immediate Response to Infection
Volume 139, Issue 5, Pages e6 (November 2010)
Figure 2 Therapeutic targeting of the PI3K/AKT/mTOR pathway
Figure 1 A schematic representation of the HER2 signalling pathway
Itraconazole tissue and fluid concentrations in humans as multiples of the maximal or simultaneously measured concentration in plasma (μg/ml) after systemic.
Replication of human astroviruses.
Immunology of Helicobacter pylori: Insights Into the Failure of the Immune Response and Perspectives on Vaccine Studies  Keith T. Wilson, Jean E. Crabtree 
MIC distributions of selected β-lactam antimicrobial agents for H
Stages of pathogenesis of EAEC
Examples of immune response disruption by respiratory viruses.
Mechanisms by which microbial cells might develop resistance
Mammalian arginine metabolism pathway in macrophages.
Characterization of oprD promoter elements.
Schematic representation of signaling by high-risk human papillomavirus HPV E7. Schematic representation of signaling by high-risk human papillomavirus.
Phylogenetic tree showing generic and species positions based on Bayesian analysis of the nuclear ribosomal DNA 28S region (1,200 bp) of Schistosomatidae.
Nat. Rev. Clin. Oncol. doi: /nrclinonc
Mechanisms of action of antibacterial peptides.
Scheme of dynamic SCV development in the course from acute to chronic infection. Scheme of dynamic SCV development in the course from acute to chronic.
Schematic representation of signaling by MCV large T antigen (T-Ag) and small t antigen (t-Ag). Schematic representation of signaling by MCV large T antigen.
MexT-associated downregulation of oprD expression.
B19V infection of human erythroid progenitor cells (B19V life cycle).
Glucose concentration-dependent increase of melanin synthesis.
Association of IL-33 with asthma during RSV infection.
NO-metabolism-related anti-cancer strategies.
Fig. 3 Conditionally expressed CAR using Notch as a signal induction and response pathway system. Conditionally expressed CAR using Notch as a signal induction.
Relationships between H. pylori, inflammation, and acid secretion.
Structure of PrfA (A) and its target DNA sequences in PrfA-regulated promoters (B). Structure of PrfA (A) and its target DNA sequences in PrfA-regulated.
Fluconazole tissue and fluid concentrations in humans as multiples of the maximal or simultaneously measured concentration in plasma (μg/ml) after systemic.
Number of outbreaks associated with drinking water by water system type and year (n = 780), 1971 to “Other” includes outbreaks associated with bottled.
Percentages of outbreak deficiencies (n = 671) in public water systems (n = 656) by time period, 1971 to 2006, excluding outbreaks associated with Legionella.
Schematic representation of signaling by KSHV LANA
Mechanism of macrophage apoptosis caused by H. pylori.
Phylogenetic network with concatenated 16S rRNA, 23S rRNA, groEL, rpoB, and dnaK sequences (3,009 unambiguously aligned base pairs), including 71 Coxiella-like.
Selected host cell processes targeted by Dot/Icm effectors demonstrating the complexity of LCV biogenesis and maintenance as well as the broad range of.
Β-Lactam hydrolysis of cephalosporin followed by nonenzymatic release of a leaving group (LG). β-Lactam hydrolysis of cephalosporin followed by nonenzymatic.
Number of outbreaks associated with drinking water by system type and month (n = 762), 1971 to 2006, excluding outbreaks associated with commercially bottled.
Fabrizio Dutly, and Martin Altwegg Clin. Microbiol. Rev. 2001; doi:10
Shell vial system protocols used for specific isolation of Bartonella, Coxiella burnetii, rickettsiae, or T. whipplei and for unspecific research into.
Dysregulation of the apical-junctional complex by H. pylori.
Staphylococcus aureus and Staphylococcus epidermidis cell surface proteins, known as microbial surface components recognizing adhesive matrix molecules.
Diagnostic tools for intestinal pathogenic E. coli.
Hector H. García et al. Clin. Microbiol. Rev. 2002; doi: /CMR
Fig. 1 Regulation of the intracellular spermidine pool.
Replication and intercellular transmission of HIV-1 is increased during antigen presentation. Replication and intercellular transmission of HIV-1 is increased.
Publications on biosensors for the field in general compared with the specific detection of whole bacteria. Publications on biosensors for the field in.
Serial testing with IGRAs reveals underlying phenotypes.
Roberta B. Carey et al. Clin. Microbiol. Rev. 2018; doi: /CMR
Schematic representation of 5′→3′ exonuclease cleavage of a 5′-labeled (small black star) probe with a 3′-phosphate (grey circle) extension blocker. Schematic.
General schematic for the identification of bacteria and yeast by MALDI-TOF MS using the intact-cell method. General schematic for the identification of.
Oncoprotein synthesis and mechanism of action of omacetaxine mepesuccinate. Oncoprotein synthesis and mechanism of action of omacetaxine mepesuccinate.
Schematic description of sites of action of different antifungal agents. Schematic description of sites of action of different antifungal agents. Candins.
Proposed mechanisms of Ag presentation.
Schematic representation of the control of muscle glucose uptake during exercise. Schematic representation of the control of muscle glucose uptake during.
Bacterial architecture and targets for biosensing.
S. pneumoniae adheres to endothelial cells by using PspC, which binds laminin and pIgR, enabling transcytosis across the endothelium. S. pneumoniae adheres.
Mechanisms of blood-cerebrospinal fluid penetration by bacterial pathogens. Mechanisms of blood-cerebrospinal fluid penetration by bacterial pathogens.
General overview of innate and adaptive immune responses to and regulation of black yeasts. General overview of innate and adaptive immune responses to.
Phylogenetic trees for fusion (F) and attachment (G) genes of selected HMPV isolates. Phylogenetic trees for fusion (F) and attachment (G) genes of selected.
Pathogenesis of oncogenic HPV
Publication output between 1970 and 2015 in the field of microbiology and CRS. Data for the number of publications per year were generated by using the.
A Lesson in Survival: S. aureus versus the Skin
Adherence patterns of enteric E. coli.
Cytokines and cytokine receptors involved in type I immunity in tuberculosis. Cytokines and cytokine receptors involved in type I immunity in tuberculosis.
Compartmentalized cellular functions of KDM4A.
The T3SS apparatus consists of rings that provide a continuous path across the inner (IM) and outer (OM) bacterial membranes, including the peptidoglycan.
Schematic representation of the relationships between acid resistance (urease activity and urea transport), nitrogen metabolism (ammonia production), metal.
CD8+ depletion and IFN-γ–deficient myeloid cells and lung metastasis inhibition in Tgfbr2MyeKO mice. CD8+ depletion and IFN-γ–deficient myeloid cells and.
Functions of selected IFN-inducible proteins.
Diagrammatic view of the locations of genes encoding classical HLA class I (HLA-A, -B, -C, -E, -F, and -G) and class II (DR, DQ, DP, and DM) molecules.
Presentation transcript:

Pathways involved in regulation of macrophage iNOS synthesis and NO production in response to H. pylori. Pathways involved in regulation of macrophage iNOS synthesis and NO production in response to H. pylori. The translation of iNOS protein depends on the availability of l-arginine (l-Arg). Pathogenic mechanisms that inhibit l-Arg availability for iNOS include (i) the consumption of extracellular l-Arg by H. pylori itself, through its bacterial arginase activity; (ii) the upregulation of macrophage arginase II, which depletes intracellular l-Arg; and (iii) induction of ODC that generates the polyamine spermine, which blocks uptake of l-Arg into macrophages by CAT2. The resulting effect is limitation of iNOS protein synthesis and NO production, despite high levels of iNOS mRNA. Arginase and ODC are novel targets for therapeutic intervention to enhance antimicrobial NO production and hence reduce persistent colonization that leads to chronic inflammation and cancer risk. Lydia E. Wroblewski et al. Clin. Microbiol. Rev. 2010; doi:10.1128/CMR.00011-10