Volume 4, Issue 5, Pages (June 2018)

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Volume 4, Issue 5, Pages 462-464 (June 2018) Inflammation and immune evasion coexist in Treponema pallidum–infected skin Rodolfo Trujillo, MD, Jorge Cervantes, MD, PhD, Kelly L. Hawley, PhD, Adriana R. Cruz, MD, Sankhiros Babapoor, DVM, PhD, MB(ASCP), Michael Murphy, MB, BCh, BAO, MMedSc, (NUI), Soheil S. Dadras, MD, PhD, Juan C. Salazar, MD, MPH JAAD Case Reports Volume 4, Issue 5, Pages 462-464 (June 2018) DOI: 10.1016/j.jdcr.2018.03.011 Copyright © 2018 American Academy of Dermatology, Inc. Terms and Conditions

Fig 1 Clinical presentation of secondary syphilitic lesion on posterior region of neck. JAAD Case Reports 2018 4, 462-464DOI: (10.1016/j.jdcr.2018.03.011) Copyright © 2018 American Academy of Dermatology, Inc. Terms and Conditions

Fig 2 Clinical presentation palms. JAAD Case Reports 2018 4, 462-464DOI: (10.1016/j.jdcr.2018.03.011) Copyright © 2018 American Academy of Dermatology, Inc. Terms and Conditions

Fig 3 Clinical presentation soles. JAAD Case Reports 2018 4, 462-464DOI: (10.1016/j.jdcr.2018.03.011) Copyright © 2018 American Academy of Dermatology, Inc. Terms and Conditions

Fig 4 Neck punch biopsy shows psoriasiform epidermal hyperplasia overlying a dermal band-like infiltrate of monocytes. (Hematoxylin-eosin stain: original magnification: ×200.) JAAD Case Reports 2018 4, 462-464DOI: (10.1016/j.jdcr.2018.03.011) Copyright © 2018 American Academy of Dermatology, Inc. Terms and Conditions

Fig 5 Immunohistochemistry. Rabbit polyclonal anti–T pallidum antibody identifies many T pallidum microorganisms. (Original magnification: ×400.) JAAD Case Reports 2018 4, 462-464DOI: (10.1016/j.jdcr.2018.03.011) Copyright © 2018 American Academy of Dermatology, Inc. Terms and Conditions

Fig 6 Immunofluorescence. The spirochetes are stained with the red fluorophore conjugated to a rabbit polyclonal anti–T pallidum antibody. The nuclei of the cells are stained with the fluorescent blue color using DAPI. (Original magnification: ×1000.) JAAD Case Reports 2018 4, 462-464DOI: (10.1016/j.jdcr.2018.03.011) Copyright © 2018 American Academy of Dermatology, Inc. Terms and Conditions