Dietary Fructose Metabolism By Splanchnic Organs: Size Matters Javier T. Gonzalez, James A. Betts  Cell Metabolism  Volume 27, Issue 3, Pages 483-485 (March 2018) DOI: 10.1016/j.cmet.2018.02.013 Copyright © 2018 Elsevier Inc. Terms and Conditions

Figure 1 Overview of Current Evidence Pertaining to Fructose Metabolism and Metabolic Health in Mice and Humans In mice, low doses of dietary fructose are primarily metabolized by the small intestine, exposing the liver primarily to glucose and lactate. High doses of fructose saturate the intestinal capacity to metabolize fructose, exposing the liver to higher fructose concentrations. Assuming this intestinal metabolism is conserved in humans, due to humans’ relatively small gut, it is unknown at what point intestinal fructose metabolism is saturated. In humans, the metabolic fate of fructose depends not only on organ and body size, but also on whole-body energy flux. Cell Metabolism 2018 27, 483-485DOI: (10.1016/j.cmet.2018.02.013) Copyright © 2018 Elsevier Inc. Terms and Conditions