Autocrine Growth by Granulocyte Colony-Stimulating Factor in Malignant Mesothelioma Motohiro Nishimura, MD, PhD, Kyoko Itoh, MD, PhD, Kazuhiro Ito, MD,

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Presentation transcript:

Autocrine Growth by Granulocyte Colony-Stimulating Factor in Malignant Mesothelioma Motohiro Nishimura, MD, PhD, Kyoko Itoh, MD, PhD, Kazuhiro Ito, MD, PhD, Masashi Yanada, MD, Kunihiko Terauchi, MD, Shinji Fushiki, MD, PhD, Junichi Shimada, MD, PhD The Annals of Thoracic Surgery Volume 82, Issue 5, Pages 1904-1906 (November 2006) DOI: 10.1016/j.athoracsur.2006.02.009 Copyright © 2006 The Society of Thoracic Surgeons Terms and Conditions

Fig 1 (A) The tumor showed interwoven bundles of spindle cells and diffuse infiltrates of epithelioid cells (left field) with abundant cytoplasm and irregular nuclei. The infiltration of leukocytes was frequently found in the tumor. (B) Intense granulocyte-colony stimulating factor (G-CSF) immunoreactivity was found in the cytoplasm of many tumor cells. (C) More abundant immunoreactivity for G-CSF receptor was recognized in the cytoplasm of tumor cells and endothelial cells. ([A]: hematoxylin-eosin; [B]: immunohistochemistry for human G-CSF; and [C]: immunohistochemistry for human G-CSF receptor.) The Annals of Thoracic Surgery 2006 82, 1904-1906DOI: (10.1016/j.athoracsur.2006.02.009) Copyright © 2006 The Society of Thoracic Surgeons Terms and Conditions