Increased signal intensity and significant enrichment of transcription factor motifs is observed with DSG in breast tissue. Increased signal intensity.

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Increased signal intensity and significant enrichment of transcription factor motifs is observed with DSG in breast tissue. Increased signal intensity and significant enrichment of transcription factor motifs is observed with DSG in breast tissue. (A) Venn diagram showing the overlap of binding sites between the ChIP-seq profiles generated using conventional cross linker FA (blue) and FA along with DSG (red) for H3K4me3. (B) Intensity plots showing the read densities over the peaks (±5 kb) in profiles generated using FA (−) and FA along with DSG (+). The fraction of reads in peaks (FRiP score) is placed above each intensity plot. (C) Genomic distribution of H3K4me3 enriched sites that are exclusive for FA- and DSG-treated sample (FA+DSG). (D) Distribution of ER motifs around ER binding sites and FOXA1 motif around FOXA1 binding sites in prostate tissue (n = 4). (E) Scatterplot depicts the correlation of reads between the binding sites identified using FA and FA along with DSG (FA+DSG) for ER, FOXA1, and H3K27ac in breast tissue (n = 4). Abhishek A Singh et al. LSA 2019;2:e201800115 © 2018 Singh et al.