Guang-Huar Young, Vin-Cent Wu Kidney International

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Presentation transcript:

KLOTHO methylation is linked to uremic toxins and chronic kidney disease Guang-Huar Young, Vin-Cent Wu Kidney International Volume 81, Issue 7, Pages 611-612 (April 2012) DOI: 10.1038/ki.2011.461 Copyright © 2012 International Society of Nephrology Terms and Conditions

Figure 1 Potential mechanisms of uremic toxin-induced silencing of the Klotho gene in chronic kidney disease involve DNA methyltransferase-mediated regulation. 5-Aza-2dC, 5-aza-2′-deoxycytidine; DNMT, DNA methyltransferase; FGF23, fibroblast growth factor-23; IGF-1, insulin-like growth factor-1; TF, transcription factor; TGF-β, transforming growth factor-β. Kidney International 2012 81, 611-612DOI: (10.1038/ki.2011.461) Copyright © 2012 International Society of Nephrology Terms and Conditions