Advanced Alloys for Biomedical Implants

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Advanced Alloys for Biomedical Implants College of Engineering & Applied Science Materials Science and Engineering Department Advanced Alloys for Biomedical Implants by Murtatha Jamel

Why Mg Physical Properties Compatibility The density (1.7-1.85 g/cm3) is similar to human cortical bone (1.75 g/cm3) Mechanical properties, E of natural bone (10–20 GPa), Mg (41–45 GPa) Can reduce stress shielding effect Compatibility Mg has no toxic effect Can be absorbed by the body as vitamins Intake of Mg 240–420 mg/day The excess will be excreted by the kidneys and intestine Stimulates multiple enzyme system 1.Chen (2014), 9. Li (2013)

Biodegradable-Nontoxic Mg-Alloying System Objectives & Novelty Selecting alloying elements with good biocompatibility Eliminating the processing defects Reducing micro segregation by using rapid solidification. Studying the effect of cooling rate and alloying elements Studying the relationship between the grain size and alloy performance Studying the effectiveness of shifting the overall chemical potential of the alloy Novelty Biodegradable-Nontoxic Mg-Alloying System

Conclusion The grain size was reduced with increasing the cooling rate Increasing the content of alloying elements refined the structure and prompted more continuous secondary phase The rapid solidification improved the hardness by 40% Adding alloying elements further improved the hardness up to 65% The impact strength was slightly affected by the cooling rate and alloying elements The fracture morphology showed slightly less deformation with increasing the cooling rate The deformation and fracture path were significantly reduced with adding alloying elements

References Chen, Yongjun ; Xu, Zhigang ; Smith, Christopher ; Sankar, Jag. “Recent advances on the development of magnesium alloys for biodegradable implants”. Acta Biomaterialia, . (November 2014), Vol.10(11), pp.4561-4573. DOI:10.1016/j.actbio.2014.07.005. Trumbo, Paula; Schlicker, Sandra; Yates, Allison A.; Poos, Mary. “Dietary Reference Intakes for Energy, Carbohydrate, Fiber, Fat, Fatty Acids, Cholesterol, Protein and Amino Acids. Journal of the American Dietetic Association, (2002). Vol.102 (11), pp.1621-1630, DOI:10.1016/S0002-8223(02)90346-9. ASM Specialty Handbook: Magnesium and Magnesium Alloys. ASM International, edited by M. Avedesian and Hugh Baker,1999. Pp15, 51,131-144,170, 194-200. Dietary Reference Intakes (DRIs): Estimated Average Requirements Food and Nutrition Board, Institute of Medicine, National Academies, 2014, table 3. Burkhardt Arthur, Knabe Richard. “Magnesium alloy”. Feb 1948, US2231881 A. Pang, Song ; Wu, Guohua ; Liu, Wencai ; Sun, Ming ; Zhang, Yang ; Liu, Zhijie ; Ding, Wenjiang. “Effect of cooling rate on the microstructure and mechanical properties of sand-casting Mg–10Gd–3Y–0.5Zr magnesium alloy”. Materials Science & Engineering A, 1 February 2013, Vol.562, pp.152-160. Candan, S. ; Celik, M. ; Candan, E. “Effectiveness of Ti-micro alloying in relation to cooling rate on corrosion of AZ91 Mg alloy”. Journal of Alloys and Compounds, 5 July 2016, Vol.672, pp.197-203. Kelvii Wei Guo , “A Review of Magnesium/Magnesium Alloys Corrosion and its Protection”. Recent Patents on Corrosion Science, 2010, Volume 2. Nan Li, Yufeng Zheng . “Novel Magnesium Alloys Developed for Biomedical Application” Journal of Materials Science & Technology, 6/2013, Vol.29(6), pp.489-502. Bakhsheshi-Rad, Hr ; Idris, Mh ; Abdul-Kadir, Mr ; Ourdjini, A ; Medraj, M ; Daroonparvar, M ; Hamzah, E “Mechanical and bio- corrosion properties of quaternary Mg-Ca-Mn-Zn alloys compared with binary Mg-Ca alloys” Materials & Design, 2014 Jan, Vol.53, pp.283-292. Frank Witte “Reprint of: The history of biodegradable magnesium implants” Acta Biomaterialia, 1 September 2015, Vol.23, pp.S28-S40. Seelig MG. “A study of magnesium wire as an absorbable suture and ligature material”. Arch Surg 1924;8 (2):669–80. Andrews EW. “Absorbable metal clips as substitutes for ligatures in wound closure”. JAMA 1917;28:278–81.