Interleukin-21 Inhibits Dendritic Cell-Mediated T Cell Activation and Induction of Contact Hypersensitivity In Vivo Donald C. Foster, Ralf Paus Journal.

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Interleukin-21 Inhibits Dendritic Cell-Mediated T Cell Activation and Induction of Contact Hypersensitivity In Vivo Donald C. Foster, Ralf Paus Journal of Investigative Dermatology Volume 121, Issue 6, Pages 1379-1382 (December 2003) DOI: 10.1046/j.1523-1747.2003.12603.x Copyright © 2003 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 1 DC express the common γ-chain and high-affinity IL-21/-15 receptor subunits. DC were generated for 8 d and stimulated with 10 ng per mL lipopolysaccharide for 24 h or left unstimulated (medium). Journal of Investigative Dermatology 2003 121, 1379-1382DOI: (10.1046/j.1523-1747.2003.12603.x) Copyright © 2003 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 2 IL-21 reduces antigen-specific CD8+ T cell proliferation but not mixed leukocyte reaction in vitro. (A) DC were incubated in parallel to OVA(257−264) peptide with IL-15 or IL-21 for 2 h. To neutralize the effects of T cell-secreted IL-21, anti-IL-21 antibodies were added to the culture. Peptide-specific, transgenic T cells were added for an additional 72 h. T cell proliferation was estimated by [3H]thymidine uptake. The experiment was repeated twice with six replicates for each experiment; shown is the median±SD. Significance was calculated using Student's t test (**p≤0.01; *p≤0.05). CPM, counts per minute. (B) DC generated from C57BL/6 mice were incubated with allogenic T cells from BALB/c mice: DC were labeled with cytokines as described above. After 72 h, proliferation was assessed through [3H]thymidine incorporation. Journal of Investigative Dermatology 2003 121, 1379-1382DOI: (10.1046/j.1523-1747.2003.12603.x) Copyright © 2003 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 3 Short-time IL-21 labeling blocks CHS induction by DC. (A) DC were incubated with IL-15 and IL-21 for 2 h and in parallel labeled with the hapten FITC. A total of 5×105 DC were injected in the hind footpad of C57BL/6 mice (day 1). Five days later, mice were challenged on the right ear, and swelling was measured after 24 h. As control, one ear was painted with diluent and unsensitized mice were challenged with FITC. Significance was calculated between DC and DC+IL-21 using Student's t test (**p≤0.01). (B) A second injection of FITC-labeled DC was performed at day 14 after first injection. Mice were challenged on the left ear 5 d after the second injection (day 19) and swelling was measured 24 h later. Journal of Investigative Dermatology 2003 121, 1379-1382DOI: (10.1046/j.1523-1747.2003.12603.x) Copyright © 2003 The Society for Investigative Dermatology, Inc Terms and Conditions