CARD15 gene mutations and risk for early surgery in pediatric-onset Crohn’s disease  Subra Kugathasan, Nicole Collins, Karen Maresso, Raymond G. Hoffmann, Michael Stephens, Steven L. Werlin, Colin Rudolph, Ulrich Broeckel  Clinical Gastroenterology and Hepatology  Volume 2, Issue 11, Pages 1003-1009 (November 2004) DOI: 10.1016/S1542-3565(04)00452-5 Copyright © 2004 American Gastroenterological Association Terms and Conditions

Figure 1 Kaplan-Meier analysis showing patients without surgery according to the time between the diagnosis and surgery in CD without 3020insC (solid line, n = 112), and children with CD who carry at least one allele of 3020insC variant (interrupted line). There was a significant risk for surgery (P < .0001; hazard ratio, 5.8) in children with CD who carry 3020insC compared with children with CD without 3020insC during the follow-up evaluation. Clinical Gastroenterology and Hepatology 2004 2, 1003-1009DOI: (10.1016/S1542-3565(04)00452-5) Copyright © 2004 American Gastroenterological Association Terms and Conditions