Integrin αvβ3 as a target in the prevention of neointimal hyperplasia

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Integrin αvβ3 as a target in the prevention of neointimal hyperplasia Taku Kokubo, MD, Hisashi Uchida, MD, Eric T. Choi, MD Journal of Vascular Surgery Volume 45, Issue 6, Pages A33-A38 (June 2007) DOI: 10.1016/j.jvs.2007.02.069 Copyright © 2007 The Society for Vascular Surgery Terms and Conditions

Fig Leading animal models of arterial injury. A, The balloon angioplasty model results in a disruptive injury to the intima and media leading to neointimal hyperplastic lesion formation with a significant smooth muscle cell (SMC) contribution from the bone marrow. B, The carotid ligation (flow cessation) model results in little or no disruptive injury to the media. The seminal event appears to be a directional SMC migration from the media to the neointima with little or no contribution from the bone marrow. C, Like the carotid ligation model, the critical event appears to be SMC migration with minimal or no medial disruption and bone marrow contribution. Journal of Vascular Surgery 2007 45, A33-A38DOI: (10.1016/j.jvs.2007.02.069) Copyright © 2007 The Society for Vascular Surgery Terms and Conditions