Justin D Vidal, D. V. M. , Thomas C Register, Ph. D. , Madhu Gupta, Ph

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Presentation transcript:

Estrogen replacement therapy induces telomerase RNA expression in the macaque endometrium Justin D Vidal, D.V.M., Thomas C Register, Ph.D., Madhu Gupta, Ph.D., J.Mark Cline, D.V.M., Ph.D. Fertility and Sterility Volume 77, Issue 3, Pages 601-608 (March 2002) DOI: 10.1016/S0015-0282(01)03227-7

Figure 1 Representative photomicrographs of in situ hybridization autoradiography for telomerase RNA in macaque endometrium. (A) = Control animal. (B) = CEE-treated animal. (C) = Animal treated with CEE + MPA. (D) = Tamoxifen-treated animal. Hematoxylin nuclear counterstain magnified 400×. Vidal. Hormonal effects on endometrial telomerase. Fertil Steril 2002. Fertility and Sterility 2002 77, 601-608DOI: (10.1016/S0015-0282(01)03227-7)

Figure 2 Percentage area of endometrial sections covered by silver grains by in situ autoradiography for telomerase RNA in the superficial glandular (A), superficial stromal (B), basal glandular (C), and basal stromal (D) compartments of macaque endometrium. Within each frame, bars with different letters are statistically different at P<.05. Vidal. Hormonal effects on endometrial telomerase. Fertil Steril 2002. Fertility and Sterility 2002 77, 601-608DOI: (10.1016/S0015-0282(01)03227-7)

Figure 3 Percentage of endometrial cells positively stained with the proliferation marker Ki67 in the superficial glandular (A), superficial stromal (B), basal glandular (C), and basal stromal (D) compartments of macaque endometrium. Within each frame, bars with different letters are statistically different at P<.05. Vidal. Hormonal effects on endometrial telomerase. Fertil Steril 2002. Fertility and Sterility 2002 77, 601-608DOI: (10.1016/S0015-0282(01)03227-7)

Figure 4 Percentage of endometrial cells positively stained with the estrogen-responsive marker PR (progesterone receptor) in the superficial glandular (A), superficial stromal (B), basal glandular (C), and basal stromal (D) compartments of macaque endometrium. Within each frame, bars with different letters are statistically different at P<.05. Vidal. Hormonal effects on endometrial telomerase. Fertil Steril 2002. Fertility and Sterility 2002 77, 601-608DOI: (10.1016/S0015-0282(01)03227-7)