Seed sequences, coding potential, and evolutionary conservation of circRNAs. Seed sequences, coding potential, and evolutionary conservation of circRNAs.

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Seed sequences, coding potential, and evolutionary conservation of circRNAs. Seed sequences, coding potential, and evolutionary conservation of circRNAs. (A) Distribution of the maximum number of seed sequences for any miRNA found across CiCo. Note that the overwhelming majority of circRNAs only displayed few (1–4) seeds. (B) Total ORFs (left) and proportion of those with a CAI value above expected (right) found in CiCo or random control datasets (***P < 0.001; chi-squared test). (C) Whiskers–box plots showing the distribution of phyloP scores for CiCo sequences (orange) and relative shuffled controls (grey) (**P < 0.01; ***P < 0.001; t test). Martina Dori et al. LSA 2019;2:e201900354 © 2019 Dori et al.