Consort Diagram 600 pts with 644 eyes accessed for eligibility

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Presentation transcript:

Consort Diagram 600 pts with 644 eyes accessed for eligibility 554 pts studied for the effect of time from diagnosis to enucleation on mortality 46 pts met first-round exclusion criteria 44 bilateral pts with each eye group D or E 2 pts died from non-tumor cause 513 pts studied for the effect of pre-enucleation chemotherapy on mortality 41 pts met second-round exclusion criteria 12 pts received pre-enucleation chemo for less than one complete cycle 29 pts received extensive pre-enucleation treatment 177 D Eyes 336 E eyes 3 plaque 6 PPV 18 IAC 1 stem cell Factors to consider: pathologic staging, time from diagnosis to enu, neoadjuvant chemo, adjuvant chemo Dependent variable: mortality. 1 immunotherapy

Relationship between neoadjuvant chemo cycle and pathology for staged D&E Eyes Low Risk Pathology (LRP): pT1 and pT2 High Risk Pathology (HRP): pT3 and pT4

Relationship between neoadjuvant chemo cycle and mortality After Controlling for Adjuvant Chemo (Kaplan Mier Survival Analysis)