Metabolomics study of esophageal adenocarcinoma

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Presentation transcript:

Metabolomics study of esophageal adenocarcinoma Jian Zhang, MS, Lingyan Liu, MS, Siwei Wei, MS, G.A. Nagana Gowda, PhD, Zane Hammoud, MD, Kenneth A. Kesler, MD, Daniel Raftery, PhD The Journal of Thoracic and Cardiovascular Surgery Volume 141, Issue 2, Pages 469-475.e4 (February 2011) DOI: 10.1016/j.jtcvs.2010.08.025 Copyright © 2011 The American Association for Thoracic Surgery Terms and Conditions

Figure 1 PLS score plot based on the 1H NMR spectra of normal subjects, BE, HGD and esophageal cancer patients. The Journal of Thoracic and Cardiovascular Surgery 2011 141, 469-475.e4DOI: (10.1016/j.jtcvs.2010.08.025) Copyright © 2011 The American Association for Thoracic Surgery Terms and Conditions

Figure 2 Results of the PLS-DA model from the 8 metabolite markers for (A) training group (G1) and (B) test group (G2), and ROC curves using the cross-validated predicted class values for (C) G1 and (D) G2. The AUC of G1 and G2 are 0.875 and 0.888, respectively. The Journal of Thoracic and Cardiovascular Surgery 2011 141, 469-475.e4DOI: (10.1016/j.jtcvs.2010.08.025) Copyright © 2011 The American Association for Thoracic Surgery Terms and Conditions

Figure 3 PLS-DA prediction from the model based on 8 metabolite markers for BE and HGD samples. The Journal of Thoracic and Cardiovascular Surgery 2011 141, 469-475.e4DOI: (10.1016/j.jtcvs.2010.08.025) Copyright © 2011 The American Association for Thoracic Surgery Terms and Conditions

Figure 4 Simplified altered metabolism pathways for the most relevant metabolic differences between patients with esophageal cancer and control subjects. The metabolites in gray were the biomarkers observed as being upregulated in patients with esophageal cancer. The Journal of Thoracic and Cardiovascular Surgery 2011 141, 469-475.e4DOI: (10.1016/j.jtcvs.2010.08.025) Copyright © 2011 The American Association for Thoracic Surgery Terms and Conditions

Typical 1H NMR CPMG serum spectra from a healthy volunteer and a patient with esophageal cancer (bottom), and their difference spectrum (top). The Journal of Thoracic and Cardiovascular Surgery 2011 141, 469-475.e4DOI: (10.1016/j.jtcvs.2010.08.025) Copyright © 2011 The American Association for Thoracic Surgery Terms and Conditions

Box-and-whisker plots of the candidate markers Box-and-whisker plots of the candidate markers. The y-axis represents the relative concentration level of each metabolite normalized by the internal standard TSP. The Journal of Thoracic and Cardiovascular Surgery 2011 141, 469-475.e4DOI: (10.1016/j.jtcvs.2010.08.025) Copyright © 2011 The American Association for Thoracic Surgery Terms and Conditions