Subsquamous Extension of Intestinal Metaplasia Is Detected in 98% of Cases of Neoplastic Barrett's Esophagus  Mario Anders, Yasmin Lucks, Muhammad Abbas El-Masry, Alexander Quaas, Thomas Rösch, Guido Schachschal, Christina Bähr, Ulrich Gauger, Guido Sauter, Jakob R. Izbicki, Andreas H. Marx  Clinical Gastroenterology and Hepatology  Volume 12, Issue 3, Pages 405-410 (March 2014) DOI: 10.1016/j.cgh.2013.07.013 Copyright © 2014 AGA Institute Terms and Conditions

Figure 1 Flow sheet showing the course of patients treated for neoplastic BE. Clinical Gastroenterology and Hepatology 2014 12, 405-410DOI: (10.1016/j.cgh.2013.07.013) Copyright © 2014 AGA Institute Terms and Conditions

Figure 2 Scatter plot showing distribution and frequency of SSIM. Subsquamous Barrett's epithelium was seen in 108 patients, ranging from 0.2 mm (minimum) to 9.6 mm (maximum); mean 3.3. Clinical Gastroenterology and Hepatology 2014 12, 405-410DOI: (10.1016/j.cgh.2013.07.013) Copyright © 2014 AGA Institute Terms and Conditions

Figure 3 Schematic drawing of variations in SSIM extent (see text); different extents of Barrett's epithelium underneath squamous epithelium (SSIM) are shown; measurement along the green line does not show any SSIM, while maximum extent of SSIM is depicted by the blue line. C, visible circular BE length; M, total extension of visible BE tongues. Clinical Gastroenterology and Hepatology 2014 12, 405-410DOI: (10.1016/j.cgh.2013.07.013) Copyright © 2014 AGA Institute Terms and Conditions

Figure 4 Histologic slides of SSIM. (A) The oral extension of BE glands (red arrow) underneath the SQE of the esophagus measures more than 3 mm; H&E 100x. (B) Another case also showing BE extension (red arrow); Alcian blue staining, 200x. (C) Subsquamous extension of a highly differentiated intramucosal Barrett's adenocarcinoma (red arrow); H&E 200x. Clinical Gastroenterology and Hepatology 2014 12, 405-410DOI: (10.1016/j.cgh.2013.07.013) Copyright © 2014 AGA Institute Terms and Conditions