Muzaffar H. Qazilbash, Rima M

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Arsenic Trioxide with Ascorbic Acid and High-Dose Melphalan: Results of a Phase II Randomized Trial Muzaffar H. Qazilbash, Rima M. Saliba, Yago Nieto, Gaurav Parikh, Matteo Pelosini, Fatima B. Khan, Roy B. Jones, Chitra Hosing, Floralyn Mendoza, Donna M. Weber, Michael Wang, Uday Popat, Amin Alousi, Paolo Anderlini, Richard E. Champlin, Sergio Giralt, MD Biology of Blood and Marrow Transplantation Volume 14, Issue 12, Pages 1401-1407 (December 2008) DOI: 10.1016/j.bbmt.2008.09.019 Copyright © 2008 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 1 Kaplan-Meier estimates for OS and PFS probability for all 48 patients treated on the protocol. Biology of Blood and Marrow Transplantation 2008 14, 1401-1407DOI: (10.1016/j.bbmt.2008.09.019) Copyright © 2008 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 2 (A) Kaplan-Meier estimates for OS probability according to randomization to 3 treatment arms (arm 1 = no ATO, arm 2 = ATO 0.15 mg/kg, arm 3 = ATO 0.25 mg/kg). (B) Kaplan-Meier estimates for PFS probability according to randomization to 3 treatment arms (arm 1 = no ATO, arm 2 = ATO 0.15 mg/kg, arm 3 = ATO 0.25 mg/kg). Biology of Blood and Marrow Transplantation 2008 14, 1401-1407DOI: (10.1016/j.bbmt.2008.09.019) Copyright © 2008 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 3 Impact of ATO dose on melphalan AUC on the days of melphalan administration. AUC = area under the curve; DL1 = dose level 1/no ATO; DL2 = dose level 2/ATO 0.15 mg/kg; DL3 = dose level 3/ATO 0.25 mg/kg. Biology of Blood and Marrow Transplantation 2008 14, 1401-1407DOI: (10.1016/j.bbmt.2008.09.019) Copyright © 2008 American Society for Blood and Marrow Transplantation Terms and Conditions