ChIP-seq analyses in primary breast tissue.

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Presentation transcript:

ChIP-seq analyses in primary breast tissue. ChIP-seq analyses in primary breast tissue. (A) ChIP-seq overview of ERα, FOXA1, and H3K27ac binding profiles with and without DSG treatment (FA: blue. FA+DSG: red). Tag counts and gene IDs are indicated. (B) Venn diagram showing the overlap of binding sites between the ChIP-seq profiles generated using conventional cross-linker FA (blue) and FA along with DSG (red) for ERα, FOXA1, and H3K27ac. (C) Intensity plots showing the read densities over the peaks (±5 kb) in profiles generated using FA (−) and FA along with DSG (+). The FRiP score is placed above each intensity plot. (D) Genomic distribution of ERα and FOXA1 sites in samples processed with FA and DSG (FA+DSG). (E) Percentage of ERα and FOXA1 sites in FA/DSG fixed samples positive for ESR1 and FOXA1 motifs. (F) Venn diagram of union of ERα binding sites from published datasets and ERα sites identified in FA/DSG-treated sample. The intensity plot shows the read density of the previously published ERα binding sites (±5 kb). Abhishek A Singh et al. LSA 2019;2:e201800115 © 2018 Singh et al.