Src acetylation is critical for its tumorogenesis property.

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Presentation transcript:

Src acetylation is critical for its tumorogenesis property. Src acetylation is critical for its tumorogenesis property. A, In Src-null cells expressing STAT3 and Src of indicated forms, cell proliferation was measured by BrdUrd incorporation after EGF treatment. Data are mean ± SD (n = 3). Student t test was used to calculate P value. *, P < 0.05; **, P < 0.01. B and C, v-Src WT or KR mutants transformed NIH3T3 cells in colony formation (B) and were counted in each well (C). Results shown are mean ± SD, n = 4. Student t test was used to calculate P value. **, P < 0.01. D–F, v-Src–transformed NIH3T3 cells were injected into nude mice. Tumors from these mice are shown at the bottom (D). Tumor weight and numbers were plotted in E and F, respectively. The data are presented as mean tumor volume + SD (n = 5 mice per group); Mann–Whitney test, *, P < 0.05; **, P < 0.01. G, Immunostaining of human breast carcinoma tissues with indicated antibodies. Arrows, either cytoplasmic CBP or the nuclear-associated human c-Src. Bar charts show the percentage of cells with indicated protein localization. Nuc, staining of protein only in nucleoplasm; Nuc/Cyt, staining of protein in both nucleoplasm and cytoplasm. Chao Huang et al. Cancer Res 2018;78:2825-2838 ©2018 by American Association for Cancer Research