Gene expression profile in diabetic KK/Ta mice

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Gene expression profile in diabetic KK/Ta mice Qiuling Fan, Toshihide Shike, Takako Shigihara, Mitsuo Tanimoto, Tomohito Gohda, Yuichiro Makita, L.I. Ning Wang, Satoshi Horikoshi, Yasuhiko Tomino Kidney International Volume 64, Issue 6, Pages 1978-1985 (December 2003) DOI: 10.1046/j.1523-1755.2003.00312.x Copyright © 2003 International Society of Nephrology Terms and Conditions

Figure 1 Quantitative trait locus (QTL) analysis of the sum of urinary albumin levels in KK/Ta×(BALB/c×KK/Ta) F1 backcross mice at 20weeks and 28weeks of age. Logarithm of odds (LOD) score curves are shown along chromosomes. The sum of urinary albumin levels showed a significant linkage with the interval at 83.0cM close to the marker D2Mit311 with a maximum LOD of 3.5 (χ2= 13.2, P = 0.0003). The number on the top of the vertical line represents the LOD score. Mapping positions of the typed microsatellite markers are indicated on the left with the Mouse Chromosome Committee cM distances from the centromere in parentheses. The potential candidate genes contained in the support interval are shown on the right side. Fold changes were calculated only for those genes showing an increased or decreased call in at least five out of the six comparisons. Symbol is: –, decreased renal expression in KK/Ta mouse. Rends is the QTL responsible for the renal disease in (New Zealand Black × New Zealand White) F1 hybrid mouse model of systemic lupus erythematosus. Kidney International 2003 64, 1978-1985DOI: (10.1046/j.1523-1755.2003.00312.x) Copyright © 2003 International Society of Nephrology Terms and Conditions

Figure 2 Results of competitive reverse transcription-polymerase chain reaction (RT-PCR). The upper bands are competitors (489bp), and the lower bands are genes of interest. The gels illustrated are representative of three KK/Ta mice (K) and two BALB/c mice (B). Kidney International 2003 64, 1978-1985DOI: (10.1046/j.1523-1755.2003.00312.x) Copyright © 2003 International Society of Nephrology Terms and Conditions