Snapshots of equilibrated structures of PrPC.

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Snapshots of equilibrated structures of PrPC. Snapshots of equilibrated structures of PrPC. (A) Free PrPC. The octarepeat region is shown in blue. Note that this region is extended and only few turns are developed. (B) Copper-bound PrPC. (C) Close-up of the octarepeat region. The intermediate segments between copper-bound histidines form turns that reverse the direction of the backbone. Several types of turns are observed. Turn 1 is a β-turn, with β-bridge between residues 62 and 67 just after the turn. In this case, the intermediate segment forms a short β-hairpin. Turn 2 is wide and cannot be classified as a turn based on the standard criteria. Turn 3 is similar to 1, with the exception that no β-bridge is formed within the segment. The atom colors are the same as in Fig. 1. Miroslav Hodak et al. PNAS 2009;106:28:11576-11581 ©2009 by National Academy of Sciences