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Volume 62, Issue 3, Pages 922-928 (September 2002) ETB receptor protects the tubulointerstitium in experimental thrombotic microangiopathy Masaomi Nangaku, Koei Yamada, Cheryl E. Gariepy, Toshio Miyata, Reiko Inagi, Kiyoshi Kurokawa, Masashi Yanagisawa, Toshiro Fujita, Richard J. Johnson Kidney International Volume 62, Issue 3, Pages 922-928 (September 2002) DOI: 10.1046/j.1523-1755.2002.00519.x Copyright © 2002 International Society of Nephrology Terms and Conditions

Figure 1 Persistent tubulointerstitial damage in thrombotic microangiopathy (TMA) rats at day 17. ETB receptor-deficient TMA rats showed severe tubulointerstitial damage (A) compared to wild-type TMA rats (B) at day 17 (PAS, ×200). Kidney International 2002 62, 922-928DOI: (10.1046/j.1523-1755.2002.00519.x) Copyright © 2002 International Society of Nephrology Terms and Conditions

Figure 2 Osteopontin (OPN) expression by damaged tubules in TMA rats at day 17. ETB receptor-deficient TMA rats (A) show greater expression of the tubular injury marker, osteopontin, compared to wild type TMA rats (B). Representative OPN-positive tubules are indicated by arrows (×200). Kidney International 2002 62, 922-928DOI: (10.1046/j.1523-1755.2002.00519.x) Copyright © 2002 International Society of Nephrology Terms and Conditions

Figure 3 Disruption of the peritubular capillary network in TMA rats at day 17. JG-12 staining demonstrated greater peritubular capillary density in wild type TMA rats (B) than in ETB receptor deficient TMA rats at day 17 (A; ×200). Double-staining with PCNA (black) and JG-12 (brown) revealed occasional proliferating peritubular capillary endothelial cells (inset, ×400). Kidney International 2002 62, 922-928DOI: (10.1046/j.1523-1755.2002.00519.x) Copyright © 2002 International Society of Nephrology Terms and Conditions