J.J. Vos, T.W.L. Scheeren, S.A. Loer, A. Hoeft, J.K.G. Wietasch

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Presentation transcript:

Do intravascular hypo- and hypervolaemia result in changes in central blood volumes? J.J. Vos, T.W.L. Scheeren, S.A. Loer, A. Hoeft, J.K.G. Wietasch British Journal of Anaesthesia Volume 116, Issue 1, Pages 46-53 (January 2016) DOI: 10.1093/bja/aev358 Copyright © 2016 The Author(s) Terms and Conditions

Fig 1 Illustration depicting the principles of the double indicator dilution technique. Indocyanine green (ICG) is injected into the right atrium. Two fiberoptic probes, placed in the pulmonary artery and ascending aorta, continuously measure ICG concentration. From the obtained dye dilution curves, mean transit times between injection site, pulmonary artery and aorta can be calculated to obtain ITBV and PBV. British Journal of Anaesthesia 2016 116, 46-53DOI: (10.1093/bja/aev358) Copyright © 2016 The Author(s) Terms and Conditions

Fig 2 Scatterplot of change in blood volume vs corresponding values of Vd circ, PBV and ITBV. The linear regression lines, together with the respective coefficients of determination (R2) are shown. British Journal of Anaesthesia 2016 116, 46-53DOI: (10.1093/bja/aev358) Copyright © 2016 The Author(s) Terms and Conditions

Fig 3 (A and B) Scatter plot of Vd circ vs PBV (a) and ITBV (b). Data are shown for values during normovolaemia (green circles) and for values when blood volume was decreased (orange circles) and increased (pink circles). The linear regression lines are shown for all data points, together with the coefficient of determination (R2). British Journal of Anaesthesia 2016 116, 46-53DOI: (10.1093/bja/aev358) Copyright © 2016 The Author(s) Terms and Conditions

Fig 4 Scatter plot of the relative volume status vs the PBV/Vd circ and ITBV/Vd circ ratio for all data points. British Journal of Anaesthesia 2016 116, 46-53DOI: (10.1093/bja/aev358) Copyright © 2016 The Author(s) Terms and Conditions

Fig 5 Correlation between Vd circ and the difference between ITBV and PBV. The linear regression line is shown together with the coefficient of determination (R2). British Journal of Anaesthesia 2016 116, 46-53DOI: (10.1093/bja/aev358) Copyright © 2016 The Author(s) Terms and Conditions