Kennedy J.M. , van Rij A.M. British Journal of Anaesthesia

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Presentation transcript:

Drug absorption from the small intestine in immediate postoperative patients Kennedy J.M. , van Rij A.M. British Journal of Anaesthesia Volume 97, Issue 2, Pages 171-180 (August 2006) DOI: 10.1093/bja/ael117 Copyright © 2006 British Journal of Anaesthesia Terms and Conditions

Fig 1 (a) Mean plasma acetaminophen levels before (open diamonds) and after operation (closed diamonds) after i.v. acetaminophen 1.0 g (bars=sem; n=6). (b) Mean plasma acetaminophen levels before (open diamonds) and after operation (closed diamonds) after oral acetaminophen 1.5 g (bars=sem; n=12). (c) The mean plasma acetaminophen levels after acetaminophen 1.5 g intraduodenal before (open diamonds) and after operation (closed diamonds) (bars = sem; n=12). British Journal of Anaesthesia 2006 97, 171-180DOI: (10.1093/bja/ael117) Copyright © 2006 British Journal of Anaesthesia Terms and Conditions

Fig 2 Comparison of preoperative oral (open diamonds) acetaminophen and postoperative duodenal (closed diamonds) acetaminophen (1.5 g) in two different patient groups, both undergoing major abdominal surgery (bars=sem; n=12). British Journal of Anaesthesia 2006 97, 171-180DOI: (10.1093/bja/ael117) Copyright © 2006 British Journal of Anaesthesia Terms and Conditions

Fig 3 Mean plasma pre- and postoperative concentrations of indocyanine green before (open diamonds) and after operation (closed diamonds) after i.v. indocyanine green (0.5 mg kg−1 over 5 min) t=0 min and t=30 min (bars=sem; n=9). British Journal of Anaesthesia 2006 97, 171-180DOI: (10.1093/bja/ael117) Copyright © 2006 British Journal of Anaesthesia Terms and Conditions

Fig 4 Mean plasma 99mTcDTPA levels before (open diamonds) and after operation (closed diamonds) after intraduodenal 99mTcDTPA(∼100 MBeq dose: bars=sem; n=10). British Journal of Anaesthesia 2006 97, 171-180DOI: (10.1093/bja/ael117) Copyright © 2006 British Journal of Anaesthesia Terms and Conditions

Fig 5 Scintiscans at 5 min intervals before (a) and after operation (b) showing the spread of 99mTcDTPA/acetaminophen mixture through the gastrointestinal tract in one patient. British Journal of Anaesthesia 2006 97, 171-180DOI: (10.1093/bja/ael117) Copyright © 2006 British Journal of Anaesthesia Terms and Conditions