Volume 121, Issue 6, Pages (December 2001)

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Volume 121, Issue 6, Pages 1339-1347 (December 2001) Up-regulation of cyclooxygenase 2 gene expression correlates with tumor angiogenesis in human colorectal cancer Fabio Cianchi, Camillo Cortesini, Paolo Bechi, Ornella Fantappiè, Luca Messerini, Alfredo Vannacci, Iacopo Sardi, Gianna Baroni, Vieri Boddi, Roberto Mazzanti, Emanuela Masini Gastroenterology Volume 121, Issue 6, Pages 1339-1347 (December 2001) DOI: 10.1053/gast.2001.29691 Copyright © 2001 American Gastroenterological Association Terms and Conditions

Fig. 1 (A–C) Cyclooxygenase-2 (COX-2) immunostaining (250×). Representative cases of cancer specimens classified as grades 0, 1, and 2, respectively. Normal colonic epithelium adjacent to the tumor showed no staining for COX-2. Gastroenterology 2001 121, 1339-1347DOI: (10.1053/gast.2001.29691) Copyright © 2001 American Gastroenterological Association Terms and Conditions

Fig. 2 (A–C) VEGF immunostaining (250×). Representative cases of cancer tissue classified as grades 0, 1, and 2, respectively. Gastroenterology 2001 121, 1339-1347DOI: (10.1053/gast.2001.29691) Copyright © 2001 American Gastroenterological Association Terms and Conditions

Fig. 3 MVD (mean values ± SEM) related to COX-2 immunostaining grade. MVD increases as the extent of COX-2 staining increases (rs = 0.41, P = 0.02). Gastroenterology 2001 121, 1339-1347DOI: (10.1053/gast.2001.29691) Copyright © 2001 American Gastroenterological Association Terms and Conditions

Fig. 4 MVD (mean values ± SEM) related to VEGF immunostaining grade. MVD increases as the extent of VEGF staining increases (rs = 0.62, P = 0.002). Gastroenterology 2001 121, 1339-1347DOI: (10.1053/gast.2001.29691) Copyright © 2001 American Gastroenterological Association Terms and Conditions

Fig. 5 Western blot analysis. Expression of COX-1 and COX-2 proteins in representative paired tissues from tumor and adjacent normal mucosa. T, tumor; N, normal mucosa; Kda, kilodalton. Gastroenterology 2001 121, 1339-1347DOI: (10.1053/gast.2001.29691) Copyright © 2001 American Gastroenterological Association Terms and Conditions

Fig. 6 Northern blot analysis. Expression of COX-2 and VEGF mRNA in representative paired tissues from tumor and adjacent normal mucosa. T, tumor; N, normal mucosa; GAPDH, glyceraldehyde phosphate dehydrogenase. Gastroenterology 2001 121, 1339-1347DOI: (10.1053/gast.2001.29691) Copyright © 2001 American Gastroenterological Association Terms and Conditions

Fig. 7 PGE2 levels (mean values ± SEM) determined in tumor tissue and adjacent normal mucosa obtained from surgical specimens (P < 0.0001). Gastroenterology 2001 121, 1339-1347DOI: (10.1053/gast.2001.29691) Copyright © 2001 American Gastroenterological Association Terms and Conditions

Fig. 8 PGE2 levels (mean values ± SEM) in metastatic (stage III and IV) and nonmetastatic (stage I and II) tumors (P = 0.03). Gastroenterology 2001 121, 1339-1347DOI: (10.1053/gast.2001.29691) Copyright © 2001 American Gastroenterological Association Terms and Conditions